Expression of nuclear factor-κB in human astrocytomas:: relation to pIκBa, vascular endothelial growth factor, Cox-2, microvascular characteristics, and survival
Expression of nuclear factor-κB in human astrocytomas:: relation to pIκBa, vascular endothelial growth factor, Cox-2, microvascular characteristics, and survival
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DOI：
10.1016/j.humpath.2008.01.020
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发表时间：
2008-08-01
期刊：
影响因子：
3.3
通讯作者：
Patsouris, Efstratios
中科院分区：
文献类型：
--
作者：
Korkolopoulou, Penelope;Levidou, Georgia;Patsouris, Efstratios
虽然NF-κ B B已被报道在各种肿瘤中被组成性激活，但关于其在星形细胞瘤中的临床意义的信息很少。在这项研究中，我们研究了NF κ B1/p50和pI κ Ba免疫组化表达与临床病理特征，血管内皮生长因子，考克斯-2，和82例星形细胞瘤患者的石蜡切片中微血管参数的关系。pI kappa Ba表达与核NF kappa B1/p50表达呈正相关（P = 0.0010），与胞浆NF kappa B1/p50表达呈负相关（P = 0.0008）。核NF κ B1/p50和pI κ Ba表达随肿瘤分级而增加（P = 0.0001和P <0.0001）。核NF κ B1/p50与血管内皮生长因子（P = 0.0079）、考克斯-2（P = 0.0500）和总血管表面积（P = 0.0430）相关，尽管后者仅在II级和III级中具有显著性。pI kappa Ba也与微血管口径呈正相关（PI kappa Ba/面积; P = 0.0087）。多变量分析选择NF κ B/p50表达作为独立的预测因子，不仅适用于整个队列（P = 0.0220），而且适用于II级和III级（P = 0.0029）以及IV级病例（P = 0.0310）。我们的研究结果表明，核NF κ B1/p50的表达是由其与I κ Ba在星形细胞瘤的相互作用，并与肿瘤分级和血管生成因子，表明核NF κ B/p50表达的重要性，在患者的预后。(C)2008年爱思唯尔公司All rights reserved.
Although NF-kappa B has been reported to be constitutively activated in various neoplasms, little information is available about its clinical significance in astrocytomas. In this study, we investigated the association of NF kappa B1/p50 and pI kappa Ba immunohistochemical expression with clinicopathologic features, vascular endothelial growth factor, Cox-2, and microvascular parameters in paraffin-c in bedded tissue from 82 patients with astrocytomas. pI kappa Ba expression was positively correlated with nuclear (P = .0010) and negatively with cytoplasmic (P = .0008) NF kappa B1/p50 expression. Nuclear NlF kappa B1/p50 and pI kappa Ba expression increased with tumor grade (P = .0001 and P < .0001). Nuclear NF kappa B1/p50 was associated with vascular endothelial growth factor (P = .0079), Cox-2 (P = .0500), and total vascular surface area (P = .0430), although the latter was significant only in grades II and III. pI kappa Ba was also positively correlated with microvessel caliber (PI kappa Ba/area; P = .0087). Multivariate analysis selected NF kappa B/p50 expression as an independent prognosticator not only for the entire cohort (P = .0220), but also for grades II and III (P = .0029) and grade IV cases (P = .0310). Our results suggest that nuclear NF kappa B1/p50 expression is dictated by its interaction with I kappa Ba in astrocytomas and is associated with tumor grade and angiogenic factors, denoting the importance of nuclear NF kappa B/p50 expression in patients' prognosis. (C) 2008 Elsevier Inc. All rights reserved.