Activity-dependent neurotrophic factor peptide (ADNF9) protects neurons against oxidative stress-induced death
Activity-dependent neurotrophic factor peptide (ADNF9) protects neurons against oxidative stress-induced death
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DOI：
10.1046/j.1471-4159.1999.0732341.x
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发表时间：
1999-12-01
影响因子：
4.7
通讯作者：
Mattson, MP
中科院分区：
文献类型：
--
作者：
Glazner, GW;Boland, F;Mattson, MP
活性依赖性神经营养因子（ADNF）和该肽的14个氨基酸片段（序列VLGGGSALLRSIPA）保护神经元免于与一系列毒性条件相关的死亡，包括淀粉样蛋白β肽，N-甲基-D-天冬氨酸，河豚毒素和神经毒性HIV包膜蛋白gp 120。我们报告说，一个更小的，9个氨基酸的片段（ADNFS）与序列SALLRSIPA有力地保护培养的胚胎第18天大鼠海马神经元氧化损伤和神经元凋亡诱导的硫酸亚铁和营养因子撤出。这种保护的特征包括维持线粒体功能和减少细胞内活性氧的积累。
Activity-dependent neurotrophic factor (ADNF) and a 14-amino acid fragment of this peptide (sequence VLGGGSALLRSIPA) protect neurons from death associated with an array of toxic conditions, including amyloid beta-peptide, N-methyl-D-aspartate, tetrodotoxin, and the neurotoxic HIV envelope coat protein gp120. We report that an even smaller, nine-amino acid fragment (ADNFS) with the sequence SALLRSIPA potently protects cultured embryonic day 18 rat hippocampal neurons from oxidative injury and neuronal apoptosis induced by FeSO4 and trophic factor withdrawal. Among the characteristics of this protection are maintenance of mitochondrial function and a reduction in accumulation of intracellular reactive oxygen species.