Metabolic Communication and Healthy Aging: Where Should We Focus Our Energy?
Metabolic Communication and Healthy Aging: Where Should We Focus Our Energy?
复制标题
DOI：
10.1016/j.devcel.2020.06.011
复制
发表时间：
2020-07-20
影响因子：
11.8
通讯作者：
Mair WB
中科院分区：
文献类型：
--
作者：
Smith HJ;Sharma A;Mair WB
衰老与代谢稳态和可塑性的丧失有关，这与多种年龄发病的病理学有因果关系。大多数干预措施——遗传、饮食和药理学——被发现可以减缓衰老并预防各种生物体中与年龄相关的疾病，都是通过针对中央代谢途径来实现的。然而，长期且普遍地针对代谢途径使得很难确定负责寿命延长的下游效应，并且通常会对生长和健康产生负面影响，从而限制了治疗潜力。深入了解代谢信号如何在组织、细胞和细胞器之间传递，为局部而非全局的代谢调节剂实现健康衰老开辟了新途径。在这篇综述中，我们讨论了针对特定组织中代谢途径的长寿效应，以及这些干预措施如何与远端细胞沟通以调节衰老。这些研究对于设计促进长寿而不会对健康造成负面影响的干预措施可能至关重要。可以操纵多种代谢途径来减缓衰老速度，但普遍这样做可能会产生负面的生理后果。史密斯等人。审查证据表明，针对特定组织中与年龄相关的中心代谢途径可以促进健康衰老，并可能避免有害影响。
Aging is associated with a loss of metabolic homeostasis and plasticity, which is causally linked to multiple age-onset pathologies. The majority of the interventions – genetic, dietary, and pharmacological – that have been found to slow aging and protect against age-related disease in various organisms do so by targeting central metabolic pathways. However, targeting metabolic pathways chronically and ubiquitously makes it difficult to define the downstream effects responsible for lifespan extension and often results in negative effects on growth and health, limiting therapeutic potential. Insight into how metabolic signals are relayed between tissues, cells, and organelles opens up new avenues to target metabolic regulators locally rather than globally for healthy aging. In this review, we discuss the pro-longevity effects of targeting metabolic pathways in specific tissues and how these interventions communicate with distal cells to modulate aging. These studies may be crucial in designing interventions that promote longevity without negative health consequences. Multiple metabolic pathways can be manipulated to slow the rate of aging, but doing so ubiquitously can have negative physiological consequences. Smith et al. review evidence that targeting central age-related metabolic pathways in specific tissues can promote healthy aging and might circumnavigate detrimental effects.
登录
查看更多内容
DOI：
10.1152/physiol.00010.2011
发表时间：
2011-08
期刊：
Physiology (Bethesda, Md.)
影响因子：
--
作者：
Cantó C;Auwerx J
通讯作者：
Auwerx J
IGF1R +/-小鼠中IGF-1R信号的降低会改变衰老吗？
影响因子：
3.7
作者：
Bokov AF;Garg N;Ikeno Y;Thakur S;Musi N;DeFronzo RA;Zhang N;Erickson RC;Gelfond J;Hubbard GB;Adamo ML;Richardson A
通讯作者：
Richardson A
影响因子：
64.8
作者：
Burnett, Camilla;Valentini, Sara;Cabreiro, Filipe;Goss, Martin;Somogyvari, Milan;Piper, Matthew D.;Hoddinott, Matthew;Sutphin, George L.;Leko, Vid;McElwee, Joshua J.;Vazquez-Manrique, Rafael P.;Orfila, Anne-Marie;Ackerman, Daniel;Au, Catherine;Vinti, Giovanna;Riesen, Michele;Howard, Ken;Neri, Christian;Bedalov, Antonio;Kaeberlein, Matt;Soti, Csaba;Partridge, Linda;Gems, David
通讯作者：
Gems, David
影响因子：
9.8
作者：
Bordone L;Motta MC;Picard F;Robinson A;Jhala US;Apfeld J;McDonagh T;Lemieux M;McBurney M;Szilvasi A;Easlon EJ;Lin SJ;Guarente L
通讯作者：
Guarente L
影响因子：
7.8
作者：
Baar EL;Carbajal KA;Ong IM;Lamming DW
通讯作者：
Lamming DW