Structure and evolution of gene regulatory networks in microbial genomes
Structure and evolution of gene regulatory networks in microbial genomes
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DOI：
10.1016/j.resmic.2007.09.001
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发表时间：
2007-12-01
影响因子：
2.6
通讯作者：
Collado-Vides, J.
中科院分区：
文献类型：
--
作者：
Janga, Sarath Chandra;Collado-Vides, J.
随着数百个微生物基因组的基因组序列的获得，从比较的角度解决几个问题以了解调控系统的结构和功能成为可能，至少在模式生物中是这样。最近的研究主要集中在拓扑性质和调控网络及其组件的进化。我们对自然网络的理解正在为将合成调控系统嵌入生物体铺平道路，使我们能够将生命系统的自然多样性扩大到我们以前从未预料到的程度。(C)2007年爱思唯尔·马森公司。版权所有。
With the availability of genome sequences for hundreds of microbial genomes, it has become possible to address several questions from a comparative perspective to understand the structure and function of regulatory systems, at least in model organisms. Recent studies have focused on topological properties and the evolution of regulatory networks and their components. Our understanding of natural networks is paving the way to embedding synthetic regulatory systems into organisms, allowing us to expand the natural diversity of living systems to an extent we had never before anticipated. (c) 2007 Elsevier Masson SAS. All rights reserved.