EFFECTS OF ANTERIOR OR DORSOMEDIAL THALAMIC IBOTENIC LESIONS ON LEARNING AND MEMORY IN RATS
EFFECTS OF ANTERIOR OR DORSOMEDIAL THALAMIC IBOTENIC LESIONS ON LEARNING AND MEMORY IN RATS
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DOI：
10.1016/s0163-1047(89)91000-5
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发表时间：
1989-05-01
期刊：
影响因子：
--
通讯作者：
JARRARD, LE
中科院分区：
文献类型：
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作者：
BERACOCHEA, DJ;JAFFARD, R;JARRARD, LE
使用Sprague-Dawley大鼠研究鹅膏蕈氨酸损伤前（A.Th.）和丘脑背内侧核对学习记忆的影响。记忆力的评估采用了时间改变任务，在一个直巷不同的试验间隔。此外，在径向迷宫和空间反转任务（SSDR）上评估空间定向和反应灵活性。结果表明，与A.Th.相比，MD大鼠需要更多的试验来学习时间改变任务，并且表现出受损的表现。对照组在最短的延迟时间（15 s）。相比之下，对照组。A.Th.当试验间隔增加到45秒时，需要较少试验来掌握任务并在15秒延迟时表现出正常表现的受试者受到损害。无论病变如何，在SSDR或径向迷宫中均未发现损伤，而仅发现MD病变导致与更多食物和水消耗相关的夜间多动。这些发现表明，A.Th.和MD在学习和记忆过程中的参与程度不同。MD主要参与新信息的登记，而A. Th主要参与新信息的登记。在信息的长期维护中起着重要作用。
Sprague-Dawley rats were used to study the effects of ibotenic acid lesions of the anterior (A.Th.) and the dorsomedial (MD) thalamic nuclei on learning and memory. Memory was assessed by employing a temporal alteration task in a straight alley with varying intertrial intervals. In addition, spatial orientation and response flexibility were evaluated on a radial maze and a spatial reversal task (SSDR). The results indicated that MD rats required more trials to learn the temporal alteration task and exhibited impaired performance compared to A.Th. and control groups at the shortest delay (15 s). In contrast, compared to the control group. A.Th. subjects which required less trials to master the task and exhibited normal performance at the 15-s delay were impaired when the intertrial interval was increased to 45 s. Whatever the lesion, no impairments were found in the SSDR or the radial maze while only MD lesions were found to result in a night hyperactivity associated with greater food and water consumptions. These findings indicate that A.Th. and MD are differentially involved in learning and memory processes. It is suggested that the MD is mostly involved in registering new information while the A.Th. plays a role in the maintenance of information over time.