Detection of serum antibody against arrestin from patients with acute disseminated encephalomyelitis
Detection of serum antibody against arrestin from patients with acute disseminated encephalomyelitis
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DOI：
10.1620/tjem.187.65
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发表时间：
1999-01-01
影响因子：
2.2
通讯作者：
Ohguro, H
中科院分区：
文献类型：
--
作者：
Ikeda, Y;Sudoh, A;Ohguro, H
In our previous study, we found the presence of serum autoantibody against arrestin in patients with multiple sclerosis (MS), while such serum autoantibody was not detected from patients with other neurological diseases and control subjects. We suggested that serum arrestin antibody titers may be useful for the diagnosis and evaluation of the disease's course. In the present study me examined sera from 7 patients, who were initially diagnosed as having acute disseminated encephalomyelitis (ADEM), for the presence of serum antibody against arrestin, in order to study the specificity of the serum antibody among demyelinated diseases. High titers mere detected from 2 patients out of 7. One of the patients, a 4 year-old girl, presented with an additional neurological attack during the 6 months after the initial attack, resulting in change of diagnosis to MS. During her disease course the serum titers against arrestin fluctuated in correspondence with the disease's activity. These observations suggest that the presence of serum autoantibody against arrestin may be specific to MS and be helpful for differential diagnosis of ADEM and MS. (C) 1999 Tohoku University Medical Press.
