Learning deficits and brain monoamines in rats with congenital hyperbilirubinemia
Learning deficits and brain monoamines in rats with congenital hyperbilirubinemia
复制标题
先天性高胆红素血症大鼠的学习缺陷和脑单胺水平
DOI：
10.1016/0014-4886(82)90115-7
复制
发表时间：
1982
影响因子：
5.3
通讯作者：
J. Jew
中科院分区：
文献类型：
--
作者：
R. Swenson;J. Jew
28日龄时，先天高胆红素血症大鼠(纯合子Gunn品系)接受主动学习任务(双向快门回避)和被动学习任务(跳台回避)，并与对照组(杂合子)进行比较。疼痛足电击的跳跃阈值被用作疼痛敏感度的测量。测试后，测量了8个脑区的多巴胺和去甲肾上腺素的浓度。与对照组相比，患有黄褐斑的Gunn大鼠在两种回避任务上都表现出显著的学习迟缓。由于高胆红素血症动物和他们的对照组对电击的跳跃阈值相似，学习成绩的这些差异不能归因于对足部电击的敏感度的差异。与对照组相比，黄褐斑大鼠下丘脑和海马区的去甲肾上腺素浓度升高。黄褐斑大鼠纹状体和桥脑延髓中的多巴胺浓度降低。与对照组相比，黄褐斑大鼠的小脑明显变小，多巴胺和去甲肾上腺素的总含量显著降低。患有黄褐症的幼年Gunn大鼠的学习障碍可能与这些动物大脑中儿茶酚胺浓度的变化有关。为了确定是否发生高胆红素血症的恢复，可以对处于不同发育阶段的纯合子Gunn大鼠进行类似的行为和生化测试。
At 28 days of age, rats with congenital hyperbilirubinemia (homozygous Gunn strain) were submitted to an active learning task (two-way shuttlebox avoidance) and a passive learning task (step-down avoidance) and the results compared with controls (heterozygous littermates). Jump thresholds to painful footshock were used as measures of pain sensitivity. After testing, the concentration of dopamine and norepinephrine was measured in eight brain regions. The jaundiced Gunn rat demonstrated significant learning retardation on both avoidance tasks compared with their controls. Because jump thresholds to shock were similar in hyperbilirubinemic animals and their controls, these differences in learning performance could not be attributed to differences in sensitivity to footshock. Norepinephrine concentrations in hypothalamus and hippocampus were elevated in jaundiced rats compared with controls. In jaundiced rats, dopamine concentrations in striatum and pons-medulla were diminished. Cerebella in jaundiced rats were significantly smaller, and total content of both dopamine and norepinephrine significantly lower in jaundiced rats compared with controls. Learning deficits in young jaundiced Gunn rats may be associated with the changes in brain catecholamine concentrations found in these animals. To determine whether or not any recovery from hyperbilirubinemia occurs, similar behavioral and biochemical testing could be applied to homozygous Gunn rats at different stages in development.