Salt intake and plasma atrial natriuretic peptide and nitric oxide in hypertension
Salt intake and plasma atrial natriuretic peptide and nitric oxide in hypertension
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DOI：
10.1161/01.hyp.28.3.335
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发表时间：
1996-09-01
期刊：
影响因子：
8.3
通讯作者：
Raij, L
中科院分区：
文献类型：
--
作者：
Campese, VM;Tawadrous, M;Raij, L
为了应对高盐摄入，对盐敏感的高血压个体会保留更多的钠，并且血压升高的程度高于耐盐个体。在这项研究中，我们测试了盐敏感性是否可能至少部分与心房钠尿肽（ANP）分泌减少或一氧化氮生成异常有关。我们在低盐摄入量（10 mEq/d）和高盐摄入量（250 mEq/d）条件下测量了 7 名血压正常的个体以及 13 名盐敏感型和 14 名患有原发性高血压的耐盐黑人的血浆 ANP 和 NO2+NO3。为了评估 ANP 分泌可能存在的种族差异，我们还测量了 6 名盐敏感型和 8 名耐盐型高血压白人在低盐摄入和高盐摄入期间的血浆 ANP。在低盐条件下，正常血压对照受试者和盐敏感和耐盐高血压黑人的血浆 ANP 水平没有差异。在高盐摄入期间，对照组和耐盐患者的血浆 ANP 水平没有变化，但盐敏感患者的血浆 ANP 水平下降。高盐饮食后 ANP 水平较低（P
In response to a high salt intake, salt-sensitive hypertensive individuals retain more sodium and manifest a rise in blood pressure greater than that in salt-resistant individuals. In this study, we tested whether salt sensitivity might be related at least in part to reduced secretion of atrial natriuretic peptide (ANP) or to abnormal nitric oxide production. We measured plasma ANP and NO2+NO3 in 7 normotensive individuals and 13 salt-sensitive and 14 salt-resistant blacks with essential hypertension under conditions of low (10 mEq/d) and high (250 mEq/d) salt intake. To evaluate possible racial differences in ANP secretion, we also measured plasma ANP in 6 salt-sensitive and 8 salt-resistant hypertensive whites during low and high salt intakes. Under low salt conditions, plasma ANP levels were not different in normotensive control subjects and salt-sensitive and salt-resistant hypertensive blacks. During high salt intake, plasma ANP levels did not change in control subjects and salt-resistant patients but decreased in salt-sensitive patients. ANP levels after high salt diet were lower (P