Effect of the acute crowding stress on the rat brown adipose tissue metabolic function
Effect of the acute crowding stress on the rat brown adipose tissue metabolic function
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DOI：
10.1016/j.cbpa.2005.09.014
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发表时间：
2005-12-01
影响因子：
2.3
通讯作者：
Davidovic, V
中科院分区：
文献类型：
--
作者：
Djordjevic, J;Cvijic, G;Davidovic, V
我们以前的研究结果表明，代谢和热应激影响肩胛间棕色脂肪组织（IBAT）的代谢活动，通过增加耗氧量，从而改变有毒的活性氧（ROS）的生产和抗氧化系统的活动。由于没有足够的证据表明心理社会应激对这些过程的影响，我们研究了急性拥挤应激对IBAT和下丘脑单胺氧化酶（MAO）活性以及IBAT抗氧化酶的影响。锰（MnSOD）、铜锌超氧化物歧化酶（CuZnSOD）和过氧化氢酶（CAT）作为应激暴露和动物返回对照条件下MAT代谢变化的相关指标。结果表明，急性拥挤应激不改变下丘脑和MAT MAO活性、ROS的产生以及MAT CuZnSOD和CAT活性。然而，所有三种抗氧化酶都只在恢复期后受到影响。看来，周边过热的大鼠在急性拥挤的压力性质的变化，成为更多的热比心理社会和抑制下丘脑传出通路参与IBAT产热调节。然而，似乎在应激终止后将动物返回到对照条件导致IBAT产热的重新激活，具有使体温正常化的趋势。(C)2005年爱思唯尔公司All rights reserved.
Our previous results have shown that metabolic and thermal stressors influence interscapular brown adipose tissue (IBAT) metabolic activity by increasing oxygen consumption and, consequently, altering the toxic reactive oxygen species (ROS) production and the antioxidative system activity. Since there is not enough evidence about the effect of psychosocial stressors on these processes, we studied the effect of acute crowding stress on the IBAT and hypothalamic monoamine oxidase (MAO) activity as well as IBAT antioxidative enzymes.. manganese (MnSOD), copper-zinc superoxide dismutase (CuZnSOD) and catalase (CAT), as the relevant indicators of MAT metabolic alternations under the stress exposure and the returning of animals to control conditions. The results indicated that acute crowding stress did not change the hypothalamic and MAT MAO activities, the generation of ROS and, consequently, the MAT CuZnSOD and CAT activities. However, all three antioxidative enzymes were affected only after the recovery period. It seems that peripheral overheating of rats during acute crowding changes the stress nature, by becoming more thermal than psychosocial and by supressing the hypothalamic efferent pathways involved in the IBAT thermogenesis regulation. However, it seems that returning of the animals to the control conditions after the stress termination causes the reactivation of IBAT thermogenesis with tendency to normalise the body temperature. (C) 2005 Elsevier Inc. All rights reserved.