Selective toxicity of dihydroartemisinin and holotransferrin toward human breast cancer cells
Selective toxicity of dihydroartemisinin and holotransferrin toward human breast cancer cells
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DOI：
10.1016/s0024-3205(01)01372-8
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发表时间：
2001-11-21
期刊：
影响因子：
6.1
通讯作者：
Lai, H
中科院分区：
文献类型：
--
作者：
Singh, NP;Lai, H
青蒿素在亚铁存在下具有细胞毒性。由于癌细胞中的铁流入量很高，青蒿素及其类似物在细胞内铁浓度增加的条件下选择性地杀死癌细胞。我们在此报告，在与全转铁蛋白（可增加癌细胞中亚铁铁的浓度）孵育后，青蒿素类似物二氢青蒿素在体外有效地杀死了一种抗辐射的人类乳腺癌细胞。同样的治疗对正常人类乳腺细胞的影响要小得多。由于在体内增加癌细胞内的铁含量相对容易，施用青蒿素类药物和细胞内铁增强化合物可能是一种简单、有效和经济的癌症治疗方法。(C) 2001爱思唯尔科学公司版权所有。
Artemisinin becomes cytotoxic in the presence of ferrous iron. Since iron influx is high in cancer cells, artemisinin and its analogs selectively kill cancer cells under conditions that increase intracellular iron concentrations. We report here that after incubation with holotransferrin, which increases the concentration of ferrous iron in cancer cells, dihydroartemisinin, an analog of artemisinin, effectively killed a type of radiation-resistant human breast cancer cell in vitro. The same treatment had considerably less effect on normal human breast cells. Since it is relatively easy to increase the iron content inside cancer cells in vivo, administration of artemisinin-like drugs and intracellular iron-enhancing compounds may be a simple, effective, and economical treatment for cancer. (C) 2001 Elsevier Science Inc. All rights reserved.