CGRP: A New Endogenous Cell Stemness Maintenance Molecule.
CGRP: A New Endogenous Cell Stemness Maintenance Molecule.
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DOI：
10.1155/2022/4107433
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发表时间：
2022
影响因子：
--
通讯作者：
Liu Q
中科院分区：
文献类型：
--
作者：
Lv X;Chen Q;Zhang S;Gao F;Liu Q
干细胞具有自我复制和多向分化的能力，但干细胞如何“维持”这种能力以及如何“决定”放弃这种状态并分化为具有特定功能的细胞的机制尚不清楚。 2021年诺贝尔生理学医学奖授予“温度与触觉受体”，让疼痛受体TRPV1-降钙素基因相关肽（CGRP）通路再次活跃。 CGRP的激活和阻断技术已应用于多种临床疾病。 CGRP基因结构和转录过程复杂，具有多个甲基化等修饰位点。自发现以来一直被认为是研究热点和难点。 TRPV1 的药物操纵和 CGRP 的抑制可能会改善新陈代谢并延长寿命。然而，TRPV1-神经肽-CGRP通路是否直接或间接参与干细胞的自我复制和多向分化尚不清楚。近年来研究发现CGRP与肿瘤干细胞的迁移和分化密切相关，这可能通过关闭或开启干细胞中CGRP基因表达以及激活多种调节干细胞生态位的方式来实现。在本研究中，我们回顾了CGRP作为一种新的细胞干性内源性转换的生物学效应的研究进展。
Stem cells have the ability of self-replication and multidirectional differentiation, but the mechanism of how stem cells “maintain” this ability and how to “decide” to give up this state and differentiate into cells with specific functions is still unknown. The Nobel Prize in physiology and medicine in 2021 was awarded to “temperature and tactile receptor,” which made the pain receptor TRPV1-calcitonin gene-related peptide (CGRP) pathway active again. The activation and blocking technology of CGRP has been applied to many clinical diseases. CGRP gene has complex structure and transcription process, with multiple methylation and other modification sites. It has been considered as a research hotspot and difficulty since its discovery. Drug manipulation of TRPV1 and inhibition of CGRP might improve metabolism and prolong longevity. However, whether the TRPV1-neuropeptide-CGRP pathway is directly or indirectly involved in stem cell self-replication and multidirectional differentiation is unclear. Recent studies have found that CGRP is closely related to the migration and differentiation of tumor stem cells, which may be realized by turning off or turning on the CGRP gene expression in stem cells and activating a variety of ways to regulate stem cell niches. In this study, we reviewed the advances in researches concentrated on the biological effects of CGRP as a new endogenous switching of cell stemness.
CALCB rs3829222 T/T基因型和CALCB低表达是唾液腺腺样囊性癌的高危因素
影响因子：
--
作者：
Dai C;Zhang B;Liao Y;Liu Q;Wu F;Lv X;Zeng K;Zhu X
通讯作者：
Zhu X
Wnt7b/β-catenin信号通路参与降钙素基因相关肽对早产大鼠高氧诱导的肺损伤的保护作用。
影响因子：
8.3
作者：
Wang S;Dang H;Xu F;Deng J;Zheng X
通讯作者：
Zheng X