Investigations into the biochemical mechanisms of pulmonary emphysema: effects of cigarette smoke on enzymes and anti-enzymes in the lung.
Investigations into the biochemical mechanisms of pulmonary emphysema: effects of cigarette smoke on enzymes and anti-enzymes in the lung.
复制标题
肺气肿生化机制的研究：香烟烟雾对肺部酶和抗酶的影响。
DOI：
10.1159/000195084
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Janoff,A
中科院分区：
文献类型：
--
作者：
Janoff,A
吸烟者肺气肿的发病机制仍知之甚少。然而，间接证据开始提供吸烟和蛋白酶-抗蛋白酶失衡假说之间的微弱联系。对弹性蛋白合成的独立影响也可能是重要的。这三个化学和细胞事件（白细胞募集，抑制剂失活，抑制组织修复）构成了一个合理的第一近似值，从其中接近这个复杂的问题。
The mechanism (s) causing emphysema in the cigarette smoker are still poorly understood. However, circumstantial evidence is beginning to provide a tenuous link between smoking and the protease-antiprotease imbalance hypothesis. Independ ent effects on elastin synthesis may also be important. This triad of chemical and cellu lar events (leukocyte recruitment, inhibitor inactivation, depressed tissue repair) consti tutes a reasonable first approximation from which to approach this complex question.