Heart Organoids and Engineered Heart Tissues: Novel Tools for Modeling Human Cardiac Biology and Disease.
Heart Organoids and Engineered Heart Tissues: Novel Tools for Modeling Human Cardiac Biology and Disease.
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DOI：
10.3390/biom11091277
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发表时间：
2021-08-26
期刊：
影响因子：
5.5
通讯作者：
Aguirre A
中科院分区：
文献类型：
--
作者：
Lewis-Israeli YR;Wasserman AH;Aguirre A
类器官是三维的体外细胞构建体，其在很大程度上概括了器官的性质和结构。它们构成了特别有用的模型来研究人类的不可接近状态，例如胚胎和胎儿发育，或成人的早期疾病进展。近年来，类器官已被用于模拟各种不同的器官和疾病状况。然而，与其他类器官类型（例如，脑、胰腺、肾、肠）。这是一个令人惊讶的事实，因为心血管疾病（CVD）和先天性心脏病（CHD）分别构成发达国家死亡率和发病率的主要原因，以及人类最常见的出生缺陷，并共同构成现代世界最大的未满足的医疗需求之一。迫切需要建立忠实地再现其生物学和功能的人类心脏体外模型，从而使基础和转化研究能够开发新的治疗方法。由于其复杂性，产生真正类似心脏的心脏类器官已被证明是困难的，但最近在克服这一障碍方面取得了重大进展。在这篇综述中，我们将讨论新的心脏类器官生成方法的进展，每种方法的优点和缺点，以及它们在推进心血管研究和治疗心脏疾病方面的转化应用。
Organoids are three-dimensional in vitro cell constructs that recapitulate organ properties and structure to a significant extent. They constitute particularly useful models to study unapproachable states in humans, such as embryonic and fetal development, or early disease progression in adults. In recent years organoids have been implemented to model a wide range of different organs and disease conditions. However, the technology for their fabrication and application to cardiovascular studies has been lagging significantly when compared to other organoid types (e.g., brain, pancreas, kidney, intestine). This is a surprising fact since cardiovascular disease (CVD) and congenital heart disease (CHD) constitute the leading cause of mortality and morbidity in the developed world, and the most common birth defect in humans, respectively, and collectively constitute one of the largest unmet medical needs in the modern world. There is a critical need to establish in vitro models of the human heart that faithfully recapitulate its biology and function, thus enabling basic and translational studies to develop new therapeutics. Generating heart organoids that truly resemble the heart has proven difficult due to its complexity, but significant progress has been made recently to overcome this obstacle. In this review, we will discuss progress in novel heart organoid generation methods, the advantages and disadvantages of each approach, and their translational applications for advancing cardiovascular studies and the treatment of heart disorders.
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影响因子：
16.6
作者：
Andersen P;Tampakakis E;Jimenez DV;Kannan S;Miyamoto M;Shin HK;Saberi A;Murphy S;Sulistio E;Chelko SP;Kwon C
通讯作者：
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作者：
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