Comparison of the expression and function of Lin28A and Lin28B in colon cancer.
Comparison of the expression and function of Lin28A and Lin28B in colon cancer.
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Lin28A和Lin28B在结肠癌中的表达及功能比较
DOI：
10.18632/oncotarget.12869
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发表时间：
2016-11-29
期刊：
影响因子：
--
通讯作者：
Li X
中科院分区：
文献类型：
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作者：
Wang T;He Y;Zhu Y;Chen M;Weng M;Yang C;Zhang Y;Ning N;Zhao R;Yang W;Jin Y;Li J;Redpath RJ;Zhang L;Jin X;Zhong Z;Zhang F;Wei Y;Shen G;Wang D;Liu Y;Wang G;Li X
Lin28A和Lin28B是高度保守的RNA结合蛋白，具有相似的结构和功能。最近的研究表明，这两个基因都作为癌基因，促进癌症的进展。然而，很少有研究同时比较两种癌基因在人类恶性肿瘤中的表达和功能。此外，虽然Lin28B在结肠癌中的表达和作用经常被报道，但Lin28A在结肠癌中的表达和功能在很大程度上是未知的。本研究首次系统地研究了Lin28A和Lin28B在结肠癌组织中的表达模式、突变状态及其相关性，并比较了Lin28A和Lin28B在体外结肠癌细胞增殖、迁移、侵袭和凋亡中的作用。我们已经表明，它们是共表达的，并且具有功能相似性，然而，它们相似功能的分子机制可能并不相同。本研究有助于阐明Lin28A和Lin28B在结肠癌进展中的相似性和差异。
Lin28A and Lin28B are highly conserved RNA binding proteins with similar structure and functions. Recent studies demonstrated that both of them act as oncogenes and promote cancer progression. However, few researches compared the expression and functions of both oncogenes in human malignant tumors at same time. Additionally, although the expression and role of Lin28B in colon cancer is frequently reported, the expression and functions of Lin28A in colon cancer are largely unknown. In this study, we have systematically evaluated the expressional pattern, mutation status and correlation of both Lin28A and Lin28B in colon cancer tissues for the first time, and compared the roles of Lin28A and Lin28B in the proliferation, migration, invasion and apoptosis of colon cancer cells in vitro. We have showed that they are co-expressed and have functional similarities, however, the molecular mechanisms underlying their similar functions may not be identical. This study contributes to clarify the similarities and differences of Lin28A and Lin28B in colon cancer progression.