A randomized controlled pilot study of inflammatory gene expression in response to a stress management intervention for stem cell transplant caregivers.
A randomized controlled pilot study of inflammatory gene expression in response to a stress management intervention for stem cell transplant caregivers.
复制标题
一项关于炎症基因表达响应干细胞移植护理人员压力管理干预的随机对照试点研究。
DOI：
10.1007/s10865-015-9709-3
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发表时间：
2016
影响因子：
3.1
通讯作者：
Cole,Steve
中科院分区：
文献类型：
--
作者：
Laudenslager,MarkL;Simoneau,TeresaL;Philips,Sam;Benitez,Patrick;Natvig,Crystal;Cole,Steve
很少有研究涉及是否与压力相关的生理变化的照顾者是可逆的心理干预减轻痛苦。我们报告促炎，交感神经和氧化应激基因表达的异基因造血干细胞移植（Allo-HSCT）患者的照顾者的压力管理。在通过排列区组随机分配到常规治疗（TAU，n = 11）或压力管理干预（心理教育、起搏呼吸和放松，PEPRR，n = 13）后，在一项包含149名护理人员的大型试验结束时选择了24名护理人员。在移植前后开始一对一提供PEPRR。对随机化前和移植后3个月完成PEPRR时采集的外周血单核细胞进行全基因组转录谱分析。差异表达基因的生物信息学分析表明，与TAU相比，接受PEPRR的护理人员中与炎症（NF-κB）、交感神经系统（CREB）和氧化应激（NRF 2）相关的转录控制途径的活性降低，与应激、抑郁和焦虑的减少一致。这表明，PEPRR可能会改变报告的痛苦的个人的转录组的影响。
Few studies have addressed whether stress-associated physiological changes in caregivers are reversible by psychological interventions mitigating distress. We report on pro-inflammatory, sympathetic, and oxidative stress gene expression in response to stress management for caregivers of allogeneic hematopoietic stem cell transplant (Allo-HSCT) patients. Following randomization by permuted block to either treatment as usual (TAU, n = 11) or a stress management intervention (PsychoEducation, Paced Respiration, and Relaxation, PEPRR, n = 13), twenty-four caregivers were selected at the conclusion of a larger trial of 149 caregivers. PEPRR was provided one-on-one beginning around transplant. Genome-wide transcriptional profiling was conducted on peripheral blood mononuclear cells collected prior to randomization and on completion of PEPRR 3 months post-transplant. Bioinformatics analysis of differentially expressed genes indicated reduced activity of transcription control pathways associated with inflammation (NF-κB), sympathetic nervous system (CREB), and oxidative stress (NRF2) in caregivers receiving PEPRR compared to TAU aligning with reductions in stress, depression, and anxiety. This suggests that PEPRR may alter transcriptomic effects reported for distressed individuals.