The influence of membrane bound proteins on phase separation and coarsening in cell membranes.
The influence of membrane bound proteins on phase separation and coarsening in cell membranes.
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DOI：
10.1039/c2cp41274h
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发表时间：
2012-10
期刊：
影响因子：
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通讯作者：
T. Witkowski;R. Backofen;A. Voigt
中科院分区：
文献类型：
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作者：
T. Witkowski;R. Backofen;A. Voigt
细胞膜脂筏存在的理论解释仍然是一个激烈争论的话题。在人工膜中很容易观察到大的微米级筏，并且可以使用相分离和粗化的热力学模型来解释。在活细胞中，这样的域没有观察到，并提出了各种模型来描述为什么系统不粗化。我们审查这些尝试批判性和显示在相场的方法，膜结合蛋白有可能解释在体外和体内观察到的不同行为。进行大规模的模拟来计算膜结合蛋白质的影响下的缩放律和大小分布函数，并观察到在较长的时间和故障的自相似性的大小分布函数的域粗化的显着放缓。
A theoretical explanation of the existence of lipid rafts in cell membranes remains a topic of lively debate. Large, micrometer sized rafts are readily observed in artificial membranes and can be explained using thermodynamic models for phase separation and coarsening. In live cells such domains are not observed and various models are proposed to describe why the systems do not coarsen. We review these attempts critically and show within a phase field approach that membrane bound proteins have the potential to explain the different behaviour observed in vitro and in vivo. Large scale simulations are performed to compute scaling laws and size distribution functions under the influence of membrane bound proteins and to observe a significant slow down of the domain coarsening at longer times and a breakdown of the self-similarity of the size-distribution function.