Late treatment-related complications in 214 patients with extremity soft-tissue sarcoma treated by surgery and postoperative radiation therapy
Late treatment-related complications in 214 patients with extremity soft-tissue sarcoma treated by surgery and postoperative radiation therapy
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DOI：
10.1016/j.amjsurg.2005.09.007
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发表时间：
2006-02-01
影响因子：
3
通讯作者：
Biti, G
中科院分区：
文献类型：
--
作者：
Livi, L;Santoni, R;Biti, G
背景资料：我们评估了长骨骨折和其他副作用的发生率在一组214例连续患者进行根治性切除软组织肉瘤的肢体，术后radiation.Methods：214例患者进行术后放疗后根治性切除软组织肉瘤的肢体; 156例（73%）接受了术后近距离放射治疗（BRT）加外束放射治疗（EBRT），58例（27%）仅接受了术后EBRT。结果：7例患者发生严重骨折，手术至骨折发生时间10 ~ 72个月，平均3.1个月。5例患者诊断为严重硬化伴肢体功能损害，3例患者诊断为周围神经损害。伤口并发症检测8 patients.Conclusions：在我们的系列，骨折和临床特征或“技术”参数之间没有统计学意义的相关性被发现，但所有经历骨折的患者（7/7）是绝经后妇女> 55岁。(c)2006 Excerpta Medica Inc. All rights reserved.
Background: We assessed the occurrence of long-bone fracture and other side effects in a group of 214 consecutive patients who underwent radical excision for soft-tissue sarcoma of the limb followed by postoperative irradiation.Methods: Two hundred fourteen patients underwent postoperative irradiation after radical excision of soft-tissue sarcoma of the limb; 156 (73%) received postoperative brachytherapy (BRT) plus external-beam radiation therapy (EBRT), and 58 (27%) underwent postoperative EBRT only. All patients were followed-up for a median time of 4.5 years (range 3 months to 10 years).Results: Seven patients developed bone fracture, which is considered severe morbidity; time between surgery and occurrence of fracture ranged between 10 and 72 months (average 3 1). Severe sclerosis with impairment of limb function was diagnosed in 5 and peripheral nerve damage in 3 patients. Wound complications were detected in 8 patients.Conclusions: In our series, no statistically significant correlation between bone fracture and clinical features or "technical" parameters was found, but all of the patients who experienced bone fracture (7 of 7) were postmenopausal women > 55 years old. (c) 2006 Excerpta Medica Inc. All rights reserved.