Frontal Lobe Contusion in Mice Chronically Impairs Prefrontal-Dependent Behavior.
Frontal Lobe Contusion in Mice Chronically Impairs Prefrontal-Dependent Behavior.
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DOI：
10.1371/journal.pone.0151418
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Rosi S
中科院分区：
文献类型：
--
作者：
Chou A;Morganti JM;Rosi S
创伤性脑损伤（TBI）是世界上慢性残疾的主要原因。中度至重度TBI通常会导致额叶区域受损，并导致认知、情感和社会行为后遗症，对生活质量产生负面影响。更具体地说，TBI患者经常在社会行为、焦虑和执行功能（如注意力、精神灵活性和任务转换）方面出现持续性缺陷。这些缺陷与前额叶皮层（PFC）功能有内在联系。目前，有一个类似的，行为特征的TBI模型调查额叶损伤，尽管流行的局灶性脑挫伤的额叶TBI患者。我们使用受控皮质撞击（CCI）模型在小鼠中产生额叶挫伤，并研究与PFC功能相关的行为变化。我们发现，小鼠单侧额叶挫伤对社会识别和逆转学习产生了长期损害，而对焦虑和完全保留规则转换和露营依赖行为的影响很小。
Traumatic brain injury (TBI) is a major cause of chronic disability in the world. Moderate to severe TBI often results in damage to the frontal lobe region and leads to cognitive, emotional, and social behavioral sequelae that negatively affect quality of life. More specifically, TBI patients often develop persistent deficits in social behavior, anxiety, and executive functions such as attention, mental flexibility, and task switching. These deficits are intrinsically associated with prefrontal cortex (PFC) functionality. Currently, there is a lack of analogous, behaviorally characterized TBI models for investigating frontal lobe injuries despite the prevalence of focal contusions to the frontal lobe in TBI patients. We used the controlled cortical impact (CCI) model in mice to generate a frontal lobe contusion and studied behavioral changes associated with PFC function. We found that unilateral frontal lobe contusion in mice produced long-term impairments to social recognition and reversal learning while having only a minor effect on anxiety and completely sparing rule shifting and hippocampal-dependent behavior.