Liver Regeneration
Liver Regeneration
复制标题
DOI：
10.1002/9781119436812.ch45
复制
发表时间：
2020-01
期刊：
影响因子：
--
通讯作者：
G. Michalopoulos
中科院分区：
文献类型：
--
作者：
G. Michalopoulos
与肝再生（LR）相关的信号已经通过在肝细胞培养物中触发增殖、在基因组修饰的小鼠中与信号消融相关的再生延迟或通过注射特定信号传导物质在体内对完整肝脏的响应来鉴定。本章将重点讨论这些信号对LR的影响。自噬调控是LR的重要组成部分。尽管部分肝切除术后的LR并不能代表肝病中最常见的肝损伤类型，但它已经成为了解控制LR的基本信号机制的一个非常有用的模型。本章推断，核雅普在调节肝脏大小中起作用，并且肝细胞生长因子/肝细胞生长因子受体和表皮生长因子/表皮生长因子受体的组合信号传导对于维持肝脏稳态是必不可少的;这些受体酪氨酸激酶信号的组合消除导致肝脏失代偿和功能崩溃。
Signals related to liver regeneration (LR) have been identified by triggering proliferation in hepatocyte cultures, delay of regeneration associated with signal ablation in genomically modified mice, or response of intact liver in vivo by injecting specific signaling substances. This chapter discusses these signals with emphasis on their effects on LR. Autophagy regulation is an important part of LR. Even though LR after partial hepatectomy is not representative of types of liver injury most commonly seen in liver disease, it has been a very useful model for understanding the fundamental signaling mechanisms controlling LR. The chapter infers that nuclear Yap plays a role in regulating liver size and that combined signaling of hepatocyte growth factor/hepatocyte growth factor receptor and epidermal growth factor/ epidermal growth factor receptor are essential for maintaining the hepatostat; combined elimination of these receptor tyrosine kinases signals causes liver decompensation and functional collapse.