Positivity of patch tests in cutaneous reaction to diclofenac
Positivity of patch tests in cutaneous reaction to diclofenac
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双氯芬酸皮肤反应斑贴试验呈阳性
DOI：
10.1111/j.1398-9995.1994.tb00774.x
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发表时间：
1994
期刊：
影响因子：
12.4
通讯作者：
C. Barone
中科院分区：
文献类型：
--
作者：
A. Romano;F. Pietrantonio;M. Fonso;A. Garcovich;C. Chiarelli;A. Venuti;C. Barone
对非甾体抗炎药的免疫介导反应并不常见。我们观察到两例在服用双氯芬酸钠后 48-72 小时发生斑丘疹。用双氯芬酸进行的斑贴试验呈阳性。组织病理学结果类似于接触性皮炎，有不同程度的真皮受累。临床、变态反应学和组织病理学模式强烈提示IV型超敏反应机制。斑贴试验在评估皮肤对药物反应的可能免疫机制方面发挥着重要作用。
Immune‐mediated reactions to NSAIDs are unusual. We have observed two cases of maculopapular eruptions occurring 48–72 h after administration of diclofenac sodium. Patch tests performed with diclofenac were positive. The histopathologic findings resembled those of contact dermatitis with different degrees of dermal involvement. Clinical, allergologic, and histopathologic patterns strongly suggest a type IV mechanism of hypersensitivity. Patch tests play an important role in the assessment of possible immunologic mechanisms underlying cutaneous reactions to drugs.