EBV replicon vector system enhances transgene expression in vivo: applications to cancer gene therapy

EBV replicon vector system enhances transgene expression in vivo: applications to cancer gene therapy
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EBV复制子载体系统增强体内转基因表达:在癌症基因治疗中的应用

DOI:
10.1002/jgm.199
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发表时间:
2001
期刊:
The Journal of Gene Medicine
影响因子:
--
通讯作者:
Y. Kaneda
Y. Kaneda
中科院分区:
--
文献类型:
--
作者:
T. Otomo;Seiji Yamamoto;R. Morishita;Y. Kaneda

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目前癌症基因疗法的主要限制是治疗基因的低表达和瞬时表达。为了在体内长期表达转基因,已经开发了Epstein-巴尔病毒(EBV)复制子载体。本研究探讨了EBV复制子载体系统的作用及其在小鼠黑色素瘤自杀基因治疗中的应用。
A major limitation of current cancer gene therapies is low and transient expression of the therapeutic gene. For long‐term expression of transgenes in vivo, an Epstein‐Barr virus (EBV) replicon vector has been developed. The present study examines the effect of the EBV replicon vector system and its application to a suicide gene therapy for melanoma in mice.
DOI: --
发表时间: 1998-11
期刊: Cancer research
影响因子: 11.2
作者:
R. Huang;Yan Fan;M. Hossain;Ao Peng;Ziao Zeng;A. Boynton
通讯作者: R. Huang;Yan Fan;M. Hossain;Ao Peng;Ziao Zeng;A. Boynton
DOI: 10.1073/pnas.90.19.9150
发表时间: 1993-10-01
影响因子: 11.1
作者:
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通讯作者: KIEFF, E
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发表时间: 1997-05-27
影响因子: 11.1
作者:
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