Gene expression of Dio2 (thyroid hormone converting enzyme) in telencephalon is linked with predisposed biological motion preference in domestic chicks.
Gene expression of Dio2 (thyroid hormone converting enzyme) in telencephalon is linked with predisposed biological motion preference in domestic chicks.
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端脑中 Dio2（甲状腺激素转换酶）的基因表达与家养雏鸡的生物运动偏好有关。
DOI：
10.1016/j.bbr.2018.04.039
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发表时间：
2018
期刊：
影响因子：
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通讯作者：
Matsushima T.
中科院分区：
文献类型：
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作者：
Takemura Y;Yamaguchi S;Aoki N;Miura M;Homma KJ;Matsushima T.
如果在孵化后的短暂敏感期进行训练，则孝顺印记会导致社会依恋的形成。结果表明，甲状腺激素（3，5，3 ′-三碘甲状腺原氨酸，T3）是决定家鸡敏感期的关键因子。印迹上调端脑中转化酶（Dio 2，2型碘甲腺原氨酸脱碘酶）的基因表达，导致脑T3含量增加。如果全身应用，T3促进老年鸡的印记，即使在敏感期结束后。印记也与视觉感知的快速发展有关。暴露于电影诱导约翰森的生物运动（BM）的倾向性偏好，和那些具有较高BM偏好的个体更容易被印迹。在这里，我们研究了Dio 2表达是否也与BM易感性相关。通过旋转红色块训练小鸡，并测试印记（实验1）和BM偏好（实验2）。为了研究行为和生理过程的时间过程，在三组之间比较端脑中的Dio 2表达：幼稚对照雏鸡，以及训练短（0.5 h）或长时间（2 h）的雏鸡。在实验1中，较高的Dio 2表达出现在2小时组比在0.5小时/对照组，但它是不相关的个人印迹得分。在实验2中，Dio 2的表达和BM偏好之间出现了显着的正相关，在2小时训练的鸡。因此，T3的记忆启动在功能上与BM偏好诱导有关，即使在最初接触人造物体时，也能成功地对自然物体进行印记。
Filial imprinting leads to the formation of social attachment if training is performed during a brief sensitive period after hatching. We found that thyroid hormone (3,5,3′-triiodothyronine, T3) acts as a critical determining factor of the sensitive period in domestic chicks. Imprinting upregulates gene expression of the converting enzyme (Dio2, type 2 iodothyronine deiodinase) in the telencephalon, leading to increased brain T3 content. If systemically applied, T3 facilitates imprinting in aged chicks even after the sensitive period is over. Imprinting is also associated with the rapid development of visual perception. Exposure to motion pictures induces a predisposed preference to Johansson’s biological motion (BM), and those individuals with higher BM preference are more easily imprinted. Here, we examined whether Dio2 expression is also linked with BM predisposition. Chicks were trained by a rotating red block, and tested for imprinting (experiment 1) and BM preference (experiment 2). To examine the time courses of behavioural and physiological processes, Dio2 expression in telencephalon was compared among three groups: naïve control chicks, and chicks trained for a short (0.5 h) or long period (2 h). In experiment 1, higher Dio2 expression appeared in the 2-h group than in the 0.5-h/control groups, but it was not correlated with the individual imprinting score. In experiment 2, a significant positive correlation appeared between Dio2 expression and BM preference in 2-h-trained chicks. Memory priming by T3 is therefore functionally linked to BM preference induction, leading to successful imprinting to natural objects even when they are initially exposed to artificial objects.