Variable CD7 expression on T cells in the leukemic phase of cutaneous T cell lymphoma (Sezary syndrome).
Variable CD7 expression on T cells in the leukemic phase of cutaneous T cell lymphoma (Sezary syndrome).
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皮肤 T 细胞淋巴瘤（塞扎里综合征）白血病期 T 细胞上的 CD7 表达存在差异。
DOI：
10.1046/j.1523-1747.2001.01456.x
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
Polansky,M
中科院分区：
文献类型：
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作者：
Vonderheid,EC;Bigler,RD;Kotecha,A;Boselli,CM;Lessin,SR;Bernengo,MG;Polansky,M
CD7在90%的正常CD4+T细胞上正常表达，但在皮肤T细胞淋巴瘤的恶性T细胞上经常缺乏。为了研究CD7表达的临床和生物学意义，我们用流式细胞术分析了42例皮肤T细胞淋巴瘤白血病期患者的血液淋巴细胞（CD4/CD8比值为10或更高，血液中有T细胞克隆的证据）的CD7表达水平。细胞的CD7表达并没有像通常认为的那样明确地分成CD7阳性或CD7阴性两个不同的亚组；然而，在早期研究中，17例以CD4+CD7+肿瘤为主的患者中有9例随着时间的推移变成了CD4+CD7，而相反的情况没有观察到。此外，在有证据表明血液中大肿瘤细胞与小肿瘤细胞共存的3例患者中，有1例观察到CD7表达不一致。在淋巴结标本中，表达CD7和其他T细胞标记物的细胞百分比与组织学证据无关。血液淋巴细胞上的CD7表达也与患者的生存、血清IgE水平或血液嗜酸性粒细胞计数无关，这一发现表明该标记物不能识别分别产生血清白细胞介素-4或-5的功能细胞亚群。我们推测，恶性T细胞上CD7的表达水平可能是体内持续抗原刺激的结果，类似于正常T细胞在衰老过程中发生的情况。
CD7, a molecule normally expressed on 90% of normal CD4+T cells, is often deficient on the malignant T cells of cutaneous T cell lymphoma. To investigate the clinical and biologic implications of CD7 expression, blood lymphocytes from 42 patients with the leukemic phase of cutaneous T cell lymphoma (CD4/CD8 ratio of 10 or more with evidence of a T cell clone in the blood) were analyzed for level of expression of CD7 by flow cytometry. CD7 expression by cells did not clearly segregate into two distinct subgroups that are either CD7 positive or CD7 negative as generally thought; however, nine of 17 patients with a predominantly CD4+CD7+tumor population on early studies became CD4+CD7‒over time whereas the converse situation was not observed. In addition, of three patients with evidence of large tumor cells in the blood coexisting with smaller cells, discordant CD7 expression was observed in one instance. In lymph node specimens, the percentage of cells expressing CD7 and other T cell markers did not correlate with histologic evidence of involvement. CD7 expression on blood lymphocytes also did not correlate with patients' survival nor to serum IgE levels or blood eosinophil counts, a finding suggesting that this marker does not identify functional cell subsets that produce serum interleukin-4 or -5, respectively. We speculate that the level of CD7 expression on malignant T cells may be the effect of sustained antigen stimulationin vivoanalogous to what has been proposed to occur with normal T cells during aging.