CSF homovanillic acid in schizotypal personality disorder.
CSF homovanillic acid in schizotypal personality disorder.
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脑脊液高香草酸在精神分裂型人格障碍中的作用。
DOI：
10.1176/ajp.150.1.149
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Davidson,M
中科院分区：
文献类型：
--
作者：
Siever,LJ;Amin,F;Coccaro,EF;Trestman,R;Silverman,J;Horvath,TB;Mahon,TR;Knott,P;Altstiel,L;Davidson,M
研究人员测量了 10 名精神分裂型人格障碍患者和 14 名其他人格障碍患者的脑脊液中高香草酸 (HVA) 浓度。精神分裂型人格障碍患者的脑脊液 HVA 浓度高于其他人格障碍患者。此外，类似精神病的精神分裂症状与脑脊液 HVA 浓度呈正相关。这些结果表明中枢多巴胺能功能障碍与精神分裂型人格障碍的精神病样症状相关。
CSF concentrations of homovanillic acid (HVA) were measured in 10 patients with schizotypal personality disorder and 14 patients with other personality disorders. The patients with schizotypal personality disorder had higher CSF HVA concentrations than the patients with other personality disorders. Furthermore, the psychotic-like schizotypal symptoms correlated positively with the CSF HVA concentrations. These results suggest a central dopaminergic dysfunction associated with the psychotic-like symptoms of schizotypal personality disorder.