Development of osteopenia in ovariectomized cynomolgus monkeys (Macaca fascicularis).
Development of osteopenia in ovariectomized cynomolgus monkeys (Macaca fascicularis).
复制标题
去势食蟹猴（Macaca fasciculis）骨质减少的发生。
DOI：
10.1016/8756-3282(95)00318-8
复制
发表时间：
1995
期刊：
影响因子：
4.1
通讯作者：
Weaver,DS
中科院分区：
文献类型：
--
作者：
Jerome,CP;Lees,CJ;Weaver,DS
此前曾在切除卵巢的非人灵长类动物中报道过脊柱骨质减少，部分原因是无法获得骨质。在这些研究中，对国内饲养和野生卵巢切除 (OVX) 和假卵巢切除 (SHAM) 食蟹猴进行双能 X 射线骨密度测定，跟踪骨质减少一年多的情况。为了促进绝对骨质减少的发展，所有饲养的动物年龄都在9岁以上，并且在实验期间的大部分时间里饲喂含0.14％钙的饮食。饲喂 0.6% 钙的 SHAM 和 OVX 野生动物都增加了骨量，但 SHAM 猴子的骨量增加率明显较低。 OVX 家养猴子在一年内骨质流失，而 SHAM 家养猴子与基线相比没有显着变化。因此，在两个实验中都出现了相对骨质减少，但只有国内饲养的动物出现了绝对骨质减少。非人灵长类动物是唯一一种在卵巢切除术后出现绝对骨质减少的动物模型。这些数据表明，卵巢切除前骨量稳定的猴子在卵巢切除后会出现绝对骨质减少，这些猴子的钙摄入量与美国女性的摄入量相当。
Spinal osteopenia that is due in part to failure to gain bone has previously been reported in ovariectomized nonhuman primates. In these studies, development of osteopenia over one year was followed by dual-energy x-ray absorptiometry in both domestically-reared and feral ovariectomized (OVX) and sham-ovariectomized (SHAM) cynomolgus monkeys. To promote development of absolute osteopenia, the domestically-reared animals were all older than nine years and were fed a diet containing 0.14% calcium for most of the experimental period. Both SHAM and OVX feral animals fed 0.6% calcium gained bone mass, with significantly lower rates of gain in SHAM monkeys. OVX domestically-reared monkeys lost bone during one year, while SHAM domestically-reared animals showed no significant change from baseline. Thus, relative osteopenia developed in both experiments, but only the domestically-reared animals developed absolute osteopenia. Nonhuman primates are the only animal model shown to develop absolute osteopenia after ovariectomy. These data suggest that absolute osteopenia develops after ovariectomy in monkeys with stable pre-ovariectomy bone mass which are fed a level of calcium comparable to that consumed by American women.