Residential Proximity to Major Roads and Preterm Births
Residential Proximity to Major Roads and Preterm Births
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DOI：
10.1097/ede.0b013e3181fe759f
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发表时间：
2011-01
期刊：
影响因子：
5.4
通讯作者：
T. Yorifuji;H. Naruse;S. Kashima;S. Ohki;T. Murakoshi;S. Takao;T. Tsuda;H. Doi
中科院分区：
文献类型：
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作者：
T. Yorifuji;H. Naruse;S. Kashima;S. Ohki;T. Murakoshi;S. Takao;T. Tsuda;H. Doi
背景：早产造成巨大的公共卫生负担，空气污染被认为是一个潜在的危险因素。我们评估了接近主要道路（作为空气污染的指标）和早产之间的关联，按胎龄和具体的临床表现分类。方法：从日本静冈围产医院维护的数据库中提取有关父母信息和出生结局的数据。我们将分析限制在1997年至2008年期间分娩活产单胎的母亲（n = 14，226）。使用地理编码的居住信息，每个出生都根据其与主要道路的接近程度进行分类。我们使用逻辑回归估计了多变量调整后的优势比及其95%置信区间（CI），以了解靠近主要道路与早产之间的关系。结果：我们发现，在所有胎龄的早产与主要道路的接近程度呈正相关。生活在200米以内的孕妇，37周前分娩的风险增加了1.5倍（95% CI = 1.2-1.8），32周前分娩的风险增加了1.6倍（1.1-2.4），28周前分娩的风险增加了1.8倍（1.0-3.2）。特别是近距离接触会增加早产、胎膜早破和妊娠高血压的风险。结论：这项研究表明，暴露于与交通有关的空气污染甚至会增加胎龄小于30周的早产风险，并提出了一种可能的机制。
Background: Preterm births cause a large public-health burden, and air pollution is considered to be a potential risk factor. We evaluated the association between proximity to major roads (as an index for air pollution) and preterm births, classified by gestational age and specific clinical manifestations. Methods: Data on parental information and birth outcomes were extracted from the database maintained by the perinatal hospital in Shizuoka, Japan. We restricted the analysis to mothers who delivered liveborn single births from 1997 to 2008 (n = 14,226). Using the geocoded residential information, each birth was classified on its proximity to major roads. We estimated the multivariate-adjusted odds ratios and their 95% confidence intervals (CIs) for the association of proximity to major roads with preterm births, using logistic regression. Results: We found positive associations between proximity to major roads and preterm births at all gestational ages. Living within 200 m increased the risk of births before 37 weeks by 1.5 times (95% CI = 1.2–1.8), birth before 32 weeks by 1.6 times (1.1–2.4), and births before 28 weeks by 1.8 times (1.0–3.2). Proximity specifically increased the risk of preterm births with preterm premature rupture of the membranes and with pregnancy hypertension. Conclusions: This study demonstrates that exposure to traffic-related air pollution increases even the risk of preterm births of less than 30 weeks' gestational age and proposes a possible mechanism.