The Improvement of Sweet Taste Sensitivity with Decrease in Serum Leptin Levels During Weight Loss in Obese Females
The Improvement of Sweet Taste Sensitivity with Decrease in Serum Leptin Levels During Weight Loss in Obese Females
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DOI：
10.1620/tjem.220.267
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发表时间：
2010-04-01
影响因子：
2.2
通讯作者：
Higashi, Akane
中科院分区：
文献类型：
--
作者：
Umabiki, Mika;Tsuzaki, Kokoro;Higashi, Akane
瘦素可能影响甜味敏感度。然而，目前还没有关于人类减肥期间甜味阈值与血清瘦素水平之间的关联的报道。我们调查了减肥过程中甜味阈值和血清瘦素水平的变化，并与瘦素受体基因多态性(Lys109Arg)有关，该基因可能与胰岛素和葡萄糖代谢有关。这项研究包括20名肥胖但其他方面健康的女性(平均年龄：55+/-7岁，体重指数：26.1+/-1.7 kg/m(2))。参与者完成了一项为期12周的减肥计划，该计划基于通过饮食和锻炼限制能量，旨在实现他们的最佳体重。甜味阈值测定采用全口味觉法。使用等位基因特异性DNA分析进行遗传分析。体重减轻后，血清瘦素水平由9·2±-4·5降至7·9±-4·9 ng/ml(P=0.014)。在蔗糖溶液中，甜味阈值也从0.59+/-0.42降至0.22+/-0.20%(p=0.004)。相比之下，携带和不携带Lys109等位基因的受试者之间的阈值变化没有差异。多元回归分析表明，血清瘦素水平的变化与甜味阈值的变化显著相关，与初始阈值水平和Lys109等位基因无关。总而言之，肥胖女性在减肥过程中血清瘦素水平显著下降，这可能与甜味阈值的降低有关。
Leptin may influence sweet taste sensitivity. However, there are no reports on an association between the sweet taste threshold and serum leptin levels during weight loss in humans. We investigated the changes in the sweet taste threshold and the serum leptin levels during a weight-loss program, in connection with a leptin receptor polymorphism (Lys109Arg) that may be related to insulin and glucose metabolism. The study included 20 obese, but otherwise healthy, females (mean age: 55 +/- 7 years, body mass index: 26.1 +/- 1.7 kg/m(2)). Participants completed a 12-week weight-loss program based on energy restriction through diet and exercise, which aimed at achieving their optimal weight. The sweet taste threshold was determined according to the whole-mouth gustatory method. Genetic analyses were performed using the allele-specific DNA assay. Serum leptin levels were decreased from 9.2 +/- 4.5 to 7.9 +/- 4.9 ng/ml (p = 0.014) after body weight loss. The sweet taste threshold also decreased significantly from 0.59 +/- 0.42 to 0.22 +/- 0.20% in a solution of sucrose (p = 0.004). In contrast, there were no differences in changes of the threshold between participants with and without the Lys109 allele. A multiple regression analysis revealed that the changes in serum leptin levels were significantly correlated with those in the sweet taste threshold, independent of the initial threshold levels and the Lys109 allele. In conclusion, the serum leptin levels are decreased significantly during a weight-loss program in obese females, which may be associated with the decrease in the sweet taste threshold.