Chemokines and pro-inflammatory cytokines in Down's syndrome: An early marker for Alzheimer-type dementia?
Chemokines and pro-inflammatory cytokines in Down's syndrome: An early marker for Alzheimer-type dementia?
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DOI：
10.1159/000063649
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发表时间：
2002-07-01
影响因子：
22.8
通讯作者：
Manconi, PE
中科院分区：
文献类型：
--
作者：
Carta, MG;Serra, P;Manconi, PE
背景。患有唐氏综合症（DS）的人表现出早期阿尔茨海默病样痴呆。有研究表明，促炎细胞因子类在阿尔茨海默病（AD）中起作用。本研究旨在验证退行性痴呆患者的促炎细胞因子与年龄、情感症状和智力下降之间是否存在不同程度的相关性。方法：病例：DS患者19例；对照组：性别和年龄匹配的个体，由围产儿缺血性损伤引起的学习障碍。根据DSM-IV评估智力低下水平；采用评估与信息评定量表测量精神病理症状。ELISA法检测血清细胞因子水平。结果：除RANTES外，DS患者的细胞因子和趋化因子水平均较高；但检测到的唯一显著差异是mip -1 α。在DS患者中发现智力迟钝程度与IL-6、mip -1 α与年龄之间存在相关性，而在对照组中则没有。结论：获得的数据表明，趋化因子可能参与了类似AD的DS的炎症和退行性过程。需要进一步的纵向研究来证实这些发现。
Background. People with Down's syndrome (DS) show early Alzheimer-like dementia. It has been suggested that the pro-inflammatory cytokine class plays a role in Alzheimer's disease (AD). The study aims at verifying whether pro-inflammatory cytokines in DS are correlated with age, affective symptoms and intellectual decline to a different degree than in subjects with non-DS learning disabilities. Methods: Cases: 19 subjects with DS; controls: sex- and age-matched individuals with learning disabilities caused by perinatal ischaemic damage. The level of mental retardation was assessed according to DSM-IV; psychopathological symptoms were measured by the Assessment and Information Rating Profile. Serum levels of cytokines were determined with ELISA. Results: DS patients showed higher levels of cytokines and chemokines, with the exception of RANTES; but the only significant difference detected was for MIP-1alpha. A correlation between the degree of mental retardation and IL-6, and between MIP-1alpha and age was found in patients with DS, but not in controls. Conclusions: The data obtained suggest a possible involvement of chemokines in the inflammatory and degenerative processes similar to AD in DS. Further longitudinal research is required to confirm these findings.