TISSUE-SPECIFIC TARGETING OF RETROVIRAL VECTORS THROUGH LIGAND-RECEPTOR INTERACTIONS
TISSUE-SPECIFIC TARGETING OF RETROVIRAL VECTORS THROUGH LIGAND-RECEPTOR INTERACTIONS
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DOI：
10.1126/science.7973726
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发表时间：
1994-11-25
期刊：
影响因子：
56.9
通讯作者：
KAN, YW
中科院分区：
文献类型：
--
作者：
KASAHARA, N;DOZY, AM;KAN, YW
靶向特定细胞类型的逆转录病毒载体的发展可能对基因治疗策略的设计具有重要意义。将含有多肽激素促红细胞生成素和嗜亲性莫洛尼鼠白血病病毒的部分env蛋白的嵌合蛋白工程化到病毒中。这种鼠病毒对携带促红细胞生成素受体的鼠细胞的感染性增加了数倍，并且对携带促红细胞生成素受体的人细胞也具有感染性。这种通过配体-受体相互作用进行的组织特异性靶向可能在多种基因递送系统中具有广泛的应用。
The development of retroviral vectors that target specific cell types could have important implications for the design of gene therapy strategies. A chimeric protein containing the polypeptide hormone erythropoietin and part of the env protein of ecotropic Moloney murine leukemia virus was engineered into the virus. This murine virus became several times more infectious for murine cells bearing the erythropoietin receptor, and it also became infectious for human cells bearing the erythropoietin receptor. This type of tissue-specific targeting by means of ligand-receptor interactions may have broad applications to a variety of gene delivery systems.