BETA-BLOCKERS AND SLEEP - A CONTROLLED TRIAL
BETA-BLOCKERS AND SLEEP - A CONTROLLED TRIAL
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DOI：
10.1007/bf00543712
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发表时间：
1985-01-01
影响因子：
2.9
通讯作者：
ALFORD, C
中科院分区：
文献类型：
--
作者：
BETTS, TA;ALFORD, C
在一项安慰剂对照试验中，研究了四种β阻滞剂阿替洛尔、心得安、美托洛尔和吲哚洛尔对睡眠的影响。随机给10名女性志愿者用药，作为她们自己的对照。受试者接受了5次测试，每次测试持续10晚(2次基线，2次低剂量，4次高剂量，2次停药)。每天早上完成一份关于主观评价前一天晚上睡眠质量的问卷。夜间记录肌肉张力、眼球运动、心率和脑电，记录在纸和磁带上。主观问卷分析显示，心得安、美托洛尔和吲哚洛尔三种脂类药物可增加夜间做梦和醒来的回忆。这些结果证实了文献中的报道，但与考虑去甲肾上腺素对睡眠影响的预期相反。对生理记录的分析证实了受试者的报告，即亲脂性药物增加了清醒时间。根据对去甲肾上腺素对睡眠影响的了解，做梦(快速眼动睡眠，REM)减少了。更多的觉醒会导致记忆中做梦的次数增加，这解释了原本自相矛盾的结果。尽管阿替洛尔对睡眠的主观测量没有影响，但这种亲水性药物也降低了REM频率，这表明它要么有某种中枢作用，要么REM减少是由于外周‘屏蔽’效应。
The effects on sleep of four β-Blockers, atenolol, propranolol, metoprolol and pindolol, were studied in a placebo-controlled trial. Drugs were administered in random order to 10 female volunteers who acted as their own controls. Subjects were tested five times, each test period lasting 10 nights (2 baseline, 2 low dose, 4 high dose, and 2 withdrawal). A questionnaire concerning subjective appreciation of the quality of the previous night's sleep was completed each morning. Night recordings of muscle tension, eye movement, heart rate and electroencephalogram were recorded on paper and magnetic tape. Analysis of the subjective questionnaires showed that recollection of dreaming and awakening in the night was increased by the three lipophilic drugs, propranolol, metoprolol, and pindolol. These results confirm reports in the literature but are contrary to those expected from considering the effects of noradrenaline on sleep. Analysis of physiological records confirmed subjects' reports that waking was increased by the lipophilic drugs. Dreaming (rapid eye movement sleep, REM) was reduced, as predicted from knowledge of the effect of noradrenaline on sleep. Increased awakening leads to an increase in remembered dreaming which explains the otherwise paradoxical results. Although atenolol had no effect on subjective measures of sleep this hydrophilic drug also reduced REM frequency, suggesting that either it has some central effect, or that REM reduction is due to a peripheral ‘shielding’ effect.