I2-catalyzed one-pot synthesis of pyrrolo[1,2-a]quinoxaline and imidazo[1,5-a]quinoxaline derivatives via sp3 and sp2 C–H cross-dehydrogenative coupling
I2-catalyzed one-pot synthesis of pyrrolo[1,2-a]quinoxaline and imidazo[1,5-a]quinoxaline derivatives via sp3 and sp2 C–H cross-dehydrogenative coupling
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DOI：
10.1039/c5qo00124b
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发表时间：
2015-07
影响因子：
5.4
通讯作者：
Zeyuan Zhang;C. Xie;Xiao Tan;G. Song;Leilin Wen;He Gao;Chen Ma
中科院分区：
文献类型：
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作者：
Zeyuan Zhang;C. Xie;Xiao Tan;G. Song;Leilin Wen;He Gao;Chen Ma
开发了一种有效的 I2 催化级联偶联方案，用于通过 sp3 和 sp2 C-H 交叉脱氢偶联合成吡咯并[1,2-a]喹喔啉和咪唑并[1,5-a]喹喔啉衍生物。在这种无金属工艺中使用了无毒、易于获得的催化剂 I2 和氧化剂 DMSO。目标化合物以良好至优异的产率获得，底物范围广泛。
An efficient I2-catalyzed cascade coupling protocol was developed for the synthesis of pyrrolo[1,2-a]quinoxaline and imidazo[1,5-a]quinoxaline derivatives via sp3 and sp2 C–H cross-dehydrogenative coupling. A nontoxic, readily available catalyst, I2, and an oxidant, DMSO, were used in this metal-free process. The target compounds were obtained in good-to-excellent yields with a broad substrate scope.