The value of transformed lymphocyte count in subclassification of non-Hodgkin's lymphoma by fine-needle aspiration.
The value of transformed lymphocyte count in subclassification of non-Hodgkin's lymphoma by fine-needle aspiration.
复制标题
转化淋巴细胞计数在细针抽吸非霍奇金淋巴瘤亚分类中的价值。
DOI：
10.1093/ajcp/108.2.143
复制
发表时间：
1997
影响因子：
3.5
通讯作者：
Mitchell R. Smith
中科院分区：
文献类型：
--
作者：
N. Young;T. Al;Zina Al;H. Ehya;Mitchell R. Smith
目前还没有确定的标准来预测淋巴瘤的分级或细胞学材料的转化。我们对细针穿刺活检（FNA）标本中的转化淋巴细胞进行计数，以确定涂片中这些细胞的百分比是否可以预测组织学分级、生物学行为或两者。在巴氏染色涂片上测定转化淋巴细胞占总淋巴细胞的百分比。之后，细胞学诊断是基于FNA时可用的临床信息、细胞形态学数据和流式细胞术数据。结果与手术活检标本的检查结果、淋巴瘤的临床表现或两者相关。在所有低度恶性或惰性淋巴瘤中，转化淋巴细胞的百分比为10%或更低。抽吸物中转化淋巴细胞计数≥ 20%为侵袭性淋巴瘤。我们也报告我们的经验，在诊断非何杰金氏淋巴瘤的细针穿刺细胞形态学检查和免疫表型流式细胞术在癌症转诊医院。这是一项初步研究，更大的系列可能有助于建立与淋巴瘤亚型相关的转化淋巴细胞计数范围。
No established criteria exist for predicting lymphoma grade or transformation in cytologic material. We counted transformed lymphocytes in fine-needle aspiration (FNA) biopsy specimens to determine whether the percentage of these cells in the smear could predict the histologic grade, the biologic behavior, or both. The percentage of transformed lymphocytes out of total lymphoid cells was determined on Papanicolaou-stained smears. Afterward, a cytodiagnosis was based on clinical information available at the time of the FNA, cytomorphologic data, and flow cytometry data. Results were correlated with results of examination of the surgical biopsy specimen, clinical behavior of the lymphoma, or both. The percentage of transformed lymphocytes was 10% or less in all low-grade or indolent lymphomas. Aspirates with transformed lymphocyte counts of 20% or greater were aggressive lymphomas. We also report our experience in the diagnosis of non-Hodgkin's lymphoma by FNA using cytomorphologic examination and immunophenotyping by flow cytometry at a cancer referral hospital. This is a preliminary study, and larger series may help establish the ranges of transformed lymphocyte counts that correlate with the lymphoma subtype.