Stability of variables associated with the metabolic syndrome from adolescence to adulthood: The Aerobics Center Longitudinal Study
Stability of variables associated with the metabolic syndrome from adolescence to adulthood: The Aerobics Center Longitudinal Study
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DOI：
10.1002/ajhb.20079
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发表时间：
2004-11-01
影响因子：
2.9
通讯作者：
Blair, SN
中科院分区：
文献类型：
--
作者：
Eisenmann, JC;Welk, GJ;Blair, SN
这项研究的目的是检查从青春期到成年期与代谢综合征相关的变量的稳定性。样本包括来自有氧运动中心纵向研究的48名受试者，他们在青春期（平均年龄= 15.8岁）进行了一次临床访视，并在成年期（平均年龄= 26.6岁）进行了一次随访。考虑了以下变量：跑步机力竭时间（TM）、体重指数（BMI）、腰围（WC）、体脂百分比（%BF）、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）、TC：HDL-C、甘油三酯（TG）、葡萄糖（GLU）、收缩压（SBP）、舒张压（DBP）和平均（MA-P）血压。使用符合WHO和ATP III代谢综合征定义的变量（WC、HDL-C、TG、MAP和GLU）计算复合危险因素评分。跟踪系数计算为偏相关，控制随访时间（平均= 11年）。所有变量的追踪系数（r值）均为中等（TM，0.53; BMI，0.64; WC; 0.79;%BF，0.44; TC，0.62; HDL-C，0.60; TG，0.54; TC：HDL-C，0.78; SBP，0.45;和MAP，0.41），但GLU（0.26）和DBP（0.21）除外。从青春期到成年期，复合风险因素评分也保持良好（0.56）。这些结果支持了以前的发现，即与代谢综合征相关的变量从青春期到成年期都有适度的跟踪。研究结果支持在儿童和青少年时期预防和治疗肥胖、动脉粥样硬化、2型糖尿病和代谢综合征。(C)2004 Wiley-Liss，Inc.
The purpose of the study was to examine the stability of variables associated with the metabolic syndrome from adolescence to adulthood. The sample included 48 subjects from the Aerobics Center Longitudinal Study who had one clinical visit during adolescence (mean age = 15.8 years) and a follow-up visit during adulthood (mean age = 26.6 years). The following variables were considered: treadmill time to exhaustion (TM), body mass index (BMI), waist circumference (WC), percent body fat (%BF), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), TC:HDL-C, triglycerides (TG), glucose (GLU), and systolic (SBP), diastolic (DBP), and mean (MA-P) blood pressure. A composite risk factor score using variables consistent with the WHO and ATP III definition of the metabolic syndrome (WC, HDL-C, TG, MAP, and GLU) was calculated. Tracking coefficients were computed as partial correlations, controlling for length of follow-up (mean = 11 years). Tracking coefficients (r values) were moderate for all variables (TM, 0.53; BMI, 0.64; WC; 0.79;%BF, 0.44; TC, 0.62; HDL-C, 0.60; TG, 0.54; TC:HDL-C, 0.78; SBP, 0.45; and MAP, 0.41), except GLU (0.26) and DBP (0.21). The composite risk factor score also tracked moderately well (0.56) from adolescence into adulthood. The results support previous findings that variables associated with the metabolic syndrome track moderately well from adolescence to adulthood. The findings support the prevention and treatment of obesity, atherosclerosis, type 2 diabetes, and the metabolic syndrome during childhood and adolescence. (C) 2004 Wiley-Liss, Inc.