Dopamine antagonism in a novel-object recognition and a novel-object place conditioning preparation with rats
Dopamine antagonism in a novel-object recognition and a novel-object place conditioning preparation with rats
复制标题
DOI：
10.1016/s0166-4328(99)00021-2
复制
发表时间：
1999-08-01
影响因子：
2.7
通讯作者：
Bevins, RA
中科院分区：
文献类型：
--
作者：
Besheer, J;Jensen, HC;Bevins, RA
接触新事物，类似于滥用药物，可以增强老鼠的位置偏好。在本实验中，多巴胺D-1受体拮抗剂SCH-23390在不干扰物体相互作用（0.01和0.03 mg/kg）或在对照组中产生地方厌恶的剂量下，阻断了由接触新物体所决定的位置偏好的增加。然而，eticlopride，一种D-2/D-3多巴胺受体拮抗剂，仅在0.3 mg/kg的剂量下（损害物体相互作用）阻断了位置偏好的条件性增加。相比之下，SCH-23390和eticlopride都不会在不干扰物体相互作用的剂量下阻止物体识别任务中对新物体的偏好。这些实验进一步证明，控制新刺激和环境之间习得关联的神经过程与药物滥用重叠。(C) 1999 Elsevier Science B.V.版权所有
Access to novel objects, similar to drugs of abuse, can enhance a place preference in rats. In the present experiments, the dopamine D-1 receptor antagonist SCH-23390 blocked an increase in place preference conditioned by access to novel objects at doses that did not interfere with object interaction (0.01 and 0.03 mg/kg) or produce a place aversion in controls. However, eticlopride, a D-2/D-3 dopamine receptor antagonist, only blocked the conditioned increase in place preference at a dose (0.3 mg/kg) that impaired object interaction. In contrast, neither SCH-23390 nor eticlopride blocked preference for the novel object in an object recognition task at doses that did not interfere with object interaction. These experiments provide further evidence that the neural processes controlling learned associations between novel stimuli and the environment overlap with drugs of abuse. (C) 1999 Elsevier Science B.V. All rights reserved.