Bone resorption stimulated by elevated serum 1,25-(OH)2-vitamin D concentrations in healthy men.

Bone resorption stimulated by elevated serum 1,25-(OH)2-vitamin D concentrations in healthy men.
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健康男性血清 1,25-(OH)2-维生素 D 浓度升高会刺激骨吸收。

DOI:
10.1038/ki.1983.193
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发表时间:
1983
影响因子:
19.6
通讯作者:
LemannJr,J
LemannJr,J
中科院分区:
医学1区
文献类型:
--
作者:
Maierhofer,WJ;Gray,RW;Cheung,HS;LemannJr,J

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方法经威斯康星州医学院人体研究审查委员会批准,在威斯康星州密尔沃基市的威斯康星州医学院临床研究中心对8名健康男性进行代谢平衡研究。所有的研究都是在受试者吃恒定的低钙全食物饮食的情况下进行的。由于研究的长度,每天交替使用两种成分几乎相同的饮食。平均每日饮食提供:Ca 4.1 ± 0.8 mmol/天,P 04 52.8 ± 5.2 mmol/天,Mg 17.4 ± 1.4 mmol/天,K 75 ± 5 mmol/天,Na 138 ± 14 mmol/天,Cl 119 ± 9 mmol/天。膳食提供的热量平均为2840270卡,其中碳水化合物占54.3%,蛋白质占13.1%,其余为脂肪。饲料中不含明胶。4名受试者适应低钙饮食4天,然后在两个6天的控制平衡期进行观察。
Methods Metabolic balance studies were carried out in eight healthy men in the Medical College of Wisconsin Clinical Research Center, Milwaukee, Wisconsin, with their consent and the approval of the Medical College of Wisconsin Human Research Review Committee. All studies were performed while the subjects ate constant whole food diets low in Ca. Because of the length of the studies, two diets of nearly identical composition were alternated daily. The average daily diet provided: Ca 4.1 0.8 mmoles/day, P04 52.8 5.2 mmoles/day, Mg 17.4 1.4 mmoles/day, K 75 5 mmoles/day, Na 138 14 mmoles/day, and Cl 119 9 mmoles/day. The diets provided an average of 2840 270 calories, 54 3% as carbohydrate, 13 1% as protein, and the remainder as fat. The diets did not contain gelatin. Four subjects were adapted to the low Ca diet for 4 days and then observed during two 6-day control balance periods.
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