Coupling 3D printing with hot-melt extrusion to produce controlled-release tablets.
Coupling 3D printing with hot-melt extrusion to produce controlled-release tablets.
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DOI：
10.1016/j.ijpharm.2016.12.049
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发表时间：
2017-03
影响因子：
5.8
通讯作者：
Jiaxiang Zhang;Xin Feng;H. Patil;R. Tiwari;M. Repka
中科院分区：
文献类型：
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作者：
Jiaxiang Zhang;Xin Feng;H. Patil;R. Tiwari;M. Repka
这项工作的主要目的是探索三维（3D）打印中耦合熔融沉积建模与热熔挤压（HME）技术的潜力，以促进增材制造，以制造具有增强缓释性能的片剂。以对乙酰氨基酚为模型药物，采用不同等级和比例的聚合物配制片剂。采用三点弯曲试验和硬度试验测定了长丝和片剂的力学性能。使用USP-II溶出仪评估3d打印片剂、直接压缩的碾压片剂和由物理混合物制备的片剂的药物释放率。通过扫描电镜观察3d打印片剂的表面形貌和横截面形貌。用差示扫描量热法和热重法分别表征了材料的晶体状态和热性能。3d打印的片剂表面光滑，结构紧凑；因此，它们比直接压缩片剂具有更好的延长药物释放率。此外，该研究清楚地证明了HME与3D打印技术耦合的可行性，该技术允许使用不同等级和比例的药物聚合物来制定药物输送系统。此外，还可以根据患者的个人需要配制配方。
The main objective of this work was to explore the potential of coupling fused deposition modeling in three-dimensional (3D) printing with hot-melt extrusion (HME) technology to facilitate additive manufacturing, in order to fabricate tablets with enhanced extended release properties. Acetaminophen was used as the model drug and different grades and ratios of polymers were used to formulate tablets. Three-point bending and hardness tests were performed to determine the mechanical properties of the filaments and tablets. 3D-printed tablets, directly compressed mill-extruded tablets, and tablets prepared from a physical mixture were evaluated for drug release rates using a USP-II dissolution apparatus. The surface and cross-sectional morphology of the 3D-printed tablets were assessed by scanning electron microscopy. Differential scanning calorimetry and thermogravimetric analysis were used to characterize the crystal states and thermal properties of materials, respectively. The 3D-printed tablets had smooth surfaces and tight structures; therefore, they showed better extended drug release rates than the directly compressed tablets did. Further, this study clearly demonstrated the feasibility of coupling HME with 3D printing technology, which allows for the formulation of drug delivery systems using different grades and ratios of pharmaceutical polymers. In addition, formulations can be made based on the personal needs of patients.