Protection of hematopoietic cells against combined O6-benzylguanine and chloroethylnitrosourea treatment by mutant forms of O6-methylguanine DNA methyltransferase.
Protection of hematopoietic cells against combined O6-benzylguanine and chloroethylnitrosourea treatment by mutant forms of O6-methylguanine DNA methyltransferase.
复制标题
通过 O6-甲基鸟嘌呤 DNA 甲基转移酶的突变形式，保护造血细胞免受 O6-苄基鸟嘌呤和氯乙基亚硝基脲联合处理。
DOI：
10.1038/sj.bmt.1702367
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发表时间：
2000
影响因子：
4.8
通讯作者：
Erickson,LC
中科院分区：
文献类型：
--
作者：
Williams,DA;Maze,R;Kurpad,C;Pegg,A;Erickson,LC
This report demonstrates that expression of the P140A O 6-methylguanine DNA methyl transferase (MGMT) mutant via retrovirus-mediated gene transfer leads to significant, but modest, resistance of cells to both 6-benzylguanine (6-BG) depletion and treatment with 1, 3-bis (2-chloroethyl)-1-nitrosourea (BCNU). Expression of the P140A/G156A double mutant appeared to be associated with reduced or unstable protein in hematopoietic cells. Bone Marrow Transplantation (2000) 25, Suppl. 2, S105–S109.
