The relationship between vascular wall shear stress and flow-mediated dilation: Endothelial function assessed by phase-contrast magnetic resonance angiography
The relationship between vascular wall shear stress and flow-mediated dilation: Endothelial function assessed by phase-contrast magnetic resonance angiography
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DOI：
10.1016/s0735-1097(01)01649-7
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发表时间：
2001-12-01
影响因子：
24
通讯作者：
Lima, JAC
中科院分区：
文献类型：
--
作者：
Silber, HA;Bluemke, DA;Lima, JAC
目标 我们寻求：1) 研究人类血管壁剪切应力与血流介导扩张 (FMD) 之间的关系，2) 研究这种关系是否可以解释为什么小动脉中 FMD 更大。 背景 动脉壁剪切应力 (WSS) 被认为是内皮依赖性 FMD 反应的主要刺激因素。然而，WSS 和 FMD 之间的关系尚未在人类中进行过研究。此外，FMD 在小动脉中更严重，但造成这种现象的原因尚不清楚。方法使用相位对比磁共振血管造影 (PMRCA)，我们测量了 18 名健康志愿者的充血 WSS 和 FMD。假设钝化抛物线速度分布计算峰值收缩期 WSS。对 9 名受试者通过 PCMRA 和超声测量的直径进行了比较。结果 血流介导的扩张与充血收缩期 WSS 峰值呈线性正比（r=0.79，p=0.0001）。血流介导的扩张与基线直径呈负相关（r=0.62，p=0.006），但充血峰值 WSS 刺激也与基线直径呈负相关（r=0.47，p=0.049）。对 9 名受试者的相差磁共振血管造影和超声直径进行了比较，并且相关性良好（r=0.84，p
Objectives We sought: 1) to investigate the relationship between vascular wall shear stress and flow-mediated dilation (FMD) in humans, and 2) to investigate whether this relationship could explain why FMD is greater in small arteries.Background Arterial wall shear stress (WSS) is considered to be the primary stimulus for the endothelial-dependent FMD response. However, the relationship between WSS and FMD has not been investigated in humans. Furthermore, FMD is greater in small arteries, though the reasons for this phenomenon are unclear.Methods Using phase-contrast magnetic resonance angiography (PMRCA), we measured hyperemic WSS and FMD in 18 healthy volunteers. Peak systolic WSS was calculated assuming a blunted parabolic velocity profile. Diameter by PCMRA and by ultrasound was compared in nine subjects.Results Flow-mediated dilation was linearly proportional to hyperemic peak systolic WSS (r=0.79, p=0.0001). Flow-mediated dilation was inversely related to baseline diameter (r=0.62, p=0.006), but the hyperemic peak WSS stimulus was also inversely related to baseline diameter (r=0.47, p=0.049). Phase-contrast magnetic resonance angiography and ultrasound diameters were compared in nine subjects and correlated well (r=0.84, p