CEREBELLUM - ESSENTIAL INVOLVEMENT IN THE CLASSICALLY-CONDITIONED EYELID RESPONSE
CEREBELLUM - ESSENTIAL INVOLVEMENT IN THE CLASSICALLY-CONDITIONED EYELID RESPONSE
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DOI：
10.1126/science.6701513
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发表时间：
1984-01-01
期刊：
影响因子：
56.9
通讯作者：
THOMPSON, RF
中科院分区：
文献类型：
--
作者：
MCCORMICK, DA;THOMPSON, RF
本研究利用兔眼睑反应的经典条件反射来研究介导离散、适应性反应的基本联想学习的神经元结构。同侧齿状间质核的损伤，而小脑皮层的损伤，消除了习得性眨眼反应。来自这些核的记录揭示了与学习反应相关的神经元反应。刺激这些记录部位会产生眼睑反应。齿状间质核在经典条件反应的学习和产生中起关键作用。
Classical conditioning of the eyelid response in the rabbit was used to investigate the neuronal structures mediating basic associative learning of discrete, adaptive responses. Lesions of the ipsilateral dentate-interpositus nuclei but not of the cerebellar cortex, abolished the learned eyeblink response. Recordings from these nuclei have revealed neuronal responses related to the learning of the response. Stimulating these recording sites produced the eyelid response. The dentate-interpositus nuclei were concluded to be critically involved in the learning and production of classically conditioned responses.