Neurophysiological predictors of gaze-contingent music reward therapy among adults with social anxiety disorder.
Neurophysiological predictors of gaze-contingent music reward therapy among adults with social anxiety disorder.
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DOI：
10.1016/j.jpsychires.2021.09.022
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发表时间：
2021-11
影响因子：
4.8
通讯作者：
Schneier F
中科院分区：
文献类型：
--
作者：
Umemoto A;Cole SL;Allison GO;Dolan S;Lazarov A;Auerbach RP;Schneier F
社交焦虑症(SAD)与对负面评价的恐惧和高度的绩效监控有关。最好的治疗只帮助了一小部分患者，而且没有建立良好的治疗反应预测因素。目前的研究调查了加工错误的个体差异是否可以预测凝视条件音乐奖励疗法(GC-MRT)的反应。基线时，年龄19-43岁的健康对照组(HC；n=20)和成年SAD患者(n=29)完成侧翼任务，同时记录脑电(EEG)数据。然后，悲伤的参与者在8周的GC-MRT中接受了长达12次的培训，旨在训练参与者的注意力从威胁转向中性的面孔。在开始治疗后9周(治疗后)和20周(随访)完成临床评估。在基线时，与HC相比，SAD组更准确地完成了任务，并表现出更高的错误相关负波(ERN)和差值对错误委托的增量功率。在控制了年龄和基线症状后，更多的负性ERN和更多的额叶中线电位(FMT)预测了治疗后自我报告的社交焦虑症状的减少，而FMT也预测了在后续评估中临床医生评级和自我报告的症状的减少。对错误的高度警惕是SAD的特征，值得进一步研究作为GC-MRT治疗反应的预测因子。
Social anxiety disorder (SAD) is associated with fear of negative evaluation and heightened performance monitoring. The best-established treatments help only a subset of patients, and there are no well-established predictors of treatment response. The current study investigated whether individual differences in processing errors might predict response to gaze-contingent music reward therapy (GC-MRT). At baseline, healthy control subjects (HC; n=20) and adults with SAD (n=29), ages 19–43 years, completed the Flanker Task while electroencephalography (EEG) data were recorded. SAD participants then received up to 12 sessions over 8 weeks of GC-MRT, designed to train participants’ attention away from threatening and toward neutral faces. Clinical assessments were completed 9- (post-treatment) and 20-weeks (follow-up) after initiating the treatment. At baseline, compared to HC, SAD performed the task more accurately and exhibited increased error-related negativity (ERN) and delta power to error commission. After controlling for age and baseline symptoms, more negative ERN and increased frontal midline theta (FMT) predicted reduced self-reported social anxiety symptoms at post-treatment, and FMT also predicted clinician-rated and self-reported symptom reduction at the follow-up assessment. Hypervigilance to error is characteristic of SAD and warrants further research as a predictor of treatment response for GC-MRT.
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影响因子：
3.7
作者：
Luck SJ;Gaspelin N
通讯作者：
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影响因子：
8.2
作者：
GEHRING, WJ;GOSS, B;DONCHIN, E
通讯作者：
DONCHIN, E
影响因子：
3.7
作者：
Judah, Matt R.;Grant, DeMond M.;Mills, Adam C.
通讯作者：
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影响因子：
12.8
作者：
Loerinc, Amanda G.;Meuret, Alicia E.;Craske, Michelle G.
通讯作者：
Craske, Michelle G.
DOI：
10.1016/j.bpsc.2017.01.004
发表时间：
2017-07
期刊：
Biological psychiatry. Cognitive neuroscience and neuroimaging
影响因子：
--
作者：
Cavanagh JF;Meyer A;Hajcak G
通讯作者：
Hajcak G