Observations on the Neurology of Endemic Cretinism
Observations on the Neurology of Endemic Cretinism
复制标题
地方性呆小病的神经病学观察
DOI：
10.1007/978-1-4613-0765-5_21
复制
发表时间：
1989
期刊：
影响因子：
--
通讯作者：
G. Delong
中科院分区：
文献类型：
--
作者：
G. Delong
地方性克汀病的神经学分析得出以下几点：1)地方性克汀病表现出连贯的临床症状，尽管在严重程度和重点上有所不同。2)临床神经功能障碍主要涉及大脑皮层、耳蜗和基底神经节的损害。3)神经性克汀病的主要运动障碍是锥体外体而不是锥体，其特征是僵硬，并伴有痉挛。除了其他因素外，这与白癜风病变一致。3)损伤模式和其他信息表明，对大脑的关键影响发生在子宫内生命的第二个三个月。对大脑的不可逆影响似乎可能是由于神经元产生的损害。
Several points emerge from a neurological analysis of endemic cretinism:1)Endemic cretinism presents a coherent clinical picture, though varying in severity and emphasis.2)The clinical neurological deficits primarily implicate impairment of cerebral cortex, cochlea and basal ganglia.3)The major motor disorder in neurological cretinism is extrapyramidal rather than pyramidal and is characterized by rigidity, with an added measure of spasticity. It is consistent with a putamino- pallidal lesion, in addition to other elements.3)The pattern of damage, and other information, indicates that the critical effect on brain occurs during the second trimester of intrauterine life. It seems likely that the irreversible effect on brain results from impairment of neuron production.