Dietary Intake of Vitamin B12 and Folic Acid Is Associated With Lower Blood Pressure in Japanese Preschool Children
Dietary Intake of Vitamin B12 and Folic Acid Is Associated With Lower Blood Pressure in Japanese Preschool Children
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DOI：
10.1038/ajh.2011.133
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发表时间：
2011-11-01
影响因子：
3.2
通讯作者：
Nagata, Chisato
中科院分区：
文献类型：
--
作者：
Tamai, Yuya;Wada, Keiko;Nagata, Chisato
背景血浆同型半胱氨酸水平升高是高血压和心血管疾病的独立危险因素，其水平受维生素B6、B12和叶酸三种维生素的调节。到目前为止，这些维生素的摄入量和血压之间的关系只在成年人中进行了研究。我们的目的是研究这三种维生素的饮食摄入量和血压的幼儿之间的关联。MethodsWe进行了一项横断面研究，在2006年在日本学龄前学校。测量了418名3-6岁儿童的血压。通过3天饮食记录评估包括维生素的饮食。在控制了年龄、性别、年龄、年龄结果维生素B12摄入量最高的四分位数比最低的四分位数平均收缩压低6.6 mm Hg，平均舒张压低5.7 mm Hg（趋势P分别为< 0.001和0.006）。叶酸摄入量最高的四分位数的平均收缩压比最低的四分位数低4.1 mm Hg（趋势P = 0.004）。维生素B6的摄入量与血压没有显着相关性。ConclusionsThe数据表明，高摄入量的叶酸和维生素B12与学龄前儿童血压水平较低。
BackgroundAn elevated plasma homocysteine level is an independent risk factor for high blood pressure and cardiovascular disease, and its level is regulated by three vitamins; vitamin B6, B12, and folic acid. Until now, the association between the intake of these vitamins and blood pressure has been examined only in adult populations. We purposed to examine the association between dietary intake of these three vitamins and blood pressure of young children.MethodsWe conducted a cross-sectional study at Japanese preschools in 2006. Blood pressure was measured among 418 children aged 3-6 years. Diets including vitamins were assessed by a 3-day dietary record. We compared the blood pressure levels among the four groups defined according to quartile of energy-adjusted vitamin intake by using analysis of covariance after controlling for age, sex, and body mass index.ResultsThe mean systolic blood pressure was 6.6 mm Hg lower and the mean diastolic blood pressure was 5.7 mm Hg lower in the highest quartile than in the lowest quartile of vitamin B12 intake (P for trend was < 0.001 and 0.006, respectively). The mean systolic blood pressure was 4.1 mm Hg lower in the highest quartile than in the lowest quartile of folic acid intake (P for trend = 0.004). Vitamin B6 intake was not significantly associated with blood pressure.ConclusionsThe data suggest that high intakes of folic acid and vitamin B12 are associated with lower levels of blood pressure among preschool children.