Complementation of the tumorigenic phenotype in human cell hybrids.
Complementation of the tumorigenic phenotype in human cell hybrids.
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人类细胞杂交体中致瘤表型的互补。
DOI：
10.1093/jnci/70.4.667
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
E. Stanbridge
中科院分区：
文献类型：
--
作者：
B. Weissman;E. Stanbridge
几种人类肿瘤细胞系的组合被融合在一起。由癌x癌和癌x淋巴母细胞融合形成的杂交群体仍然具有很高的致瘤性。然而，在癌症x肉瘤和癌x黑色素瘤杂交人群中发现了致瘤潜力的抑制。这些结果表明，肿瘤形成表型的互补可以发生，并且可能涉及至少两个不同的互补组。
Several combinations of human tumor cell lines were fused together. Hybrid populations formed from fusions between carcinoma x carcinoma and carcinoma x lymphoblastoid remained highly tumorigenic. However, suppression of tumorigenic potential was seen in carcinoma x sarcoma and carcinoma x melanoma hybrid populations. These results suggest that complementation of the tumorigenic phenotype can occur and that at least 2 different complementation groups may be involved.