Photoreceptor Sensory Cilium: Traversing the Ciliary Gate.
Photoreceptor Sensory Cilium: Traversing the Ciliary Gate.
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DOI：
10.3390/cells4040674
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发表时间：
2015-10-15
期刊：
影响因子：
6
通讯作者：
Khanna H
中科院分区：
文献类型：
--
作者：
Khanna H
纤毛是质膜的触角状延伸，几乎存在于所有细胞类型中。在眼睛的视网膜中，光感受器发展出独特的感觉纤毛。感光细胞纤毛的形成和功能的机制知之甚少，主要是因为技术限制以及无法在体外建模的特定结构和功能修饰。随着显微镜技术和分子生物化学方法的最新进展，我们现在开始了解感光细胞纤毛结构，纤毛功能及其参与人类疾病的分子基础。在这里，我将讨论的研究，揭示了新的知识如何感光纤毛调节其身份和功能，同时应对与处理光信号相关的高代谢和贩运需求。
Cilia are antenna-like extensions of the plasma membrane found in nearly all cell types. In the retina of the eye, photoreceptors develop unique sensory cilia. Not much was known about the mechanisms underlying the formation and function of photoreceptor cilia, largely because of technical limitations and the specific structural and functional modifications that cannot be modeled in vitro. With recent advances in microscopy techniques and molecular and biochemical approaches, we are now beginning to understand the molecular basis of photoreceptor ciliary architecture, ciliary function and its involvement in human diseases. Here, I will discuss the studies that have revealed new knowledge of how photoreceptor cilia regulate their identity and function while coping with high metabolic and trafficking demands associated with processing light signal.