Efficient Covalent Capture of 8-Nitroguanosine via a Multiple Hydrogen-Bonded Complex
Efficient Covalent Capture of 8-Nitroguanosine via a Multiple Hydrogen-Bonded Complex
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DOI：
10.1021/ol500452r
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发表时间：
2014-03-21
期刊：
影响因子：
5.2
通讯作者：
Sasaki, Shigeki
中科院分区：
文献类型：
--
作者：
Fuchi, Yasufumi;Sasaki, Shigeki
一种新型的含有硫醇基团的1，3-二氮杂并恶嗪核苷衍生物(NitroG-GRGRAP)与8-硝基鸟苷形成多个氢键络合物，并有效地取代了硝基，是第一个能够共价捕获8-硝基鸟苷的分子。
A novel 1,3-diazaphenoxazine nucleoside derivative (nitroG-Grasp) bearing a thiol group with a urea linker forms multiple hydrogen-bonded complexes with 8-nitroguanosine and efficiently displaces the nitro group; thus, it is the first molecule that can covalently capture 8-nitroguanosine.