Ion channels and signal transduction in lymphocytes.
Ion channels and signal transduction in lymphocytes.
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淋巴细胞中的离子通道和信号转导。
DOI：
10.1146/annurev.ph.52.030190.002215
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发表时间：
1990
影响因子：
18.2
通讯作者：
Cahalan,MD
中科院分区：
文献类型：
--
作者：
Lewis,RS;Cahalan,MD
T淋巴细胞和B淋巴细胞在免疫反应中发挥着基础和多种作用，包括识别抗原，分泌淋巴因子和抗体，杀死外来或病毒感染的细胞。离子通量与淋巴细胞活化、有丝分裂和体积调节有关，已在细胞悬液中进行了广泛的研究（有关综述，见67、103、124，Grinstein & Foskett，本卷）。最近，膜片钳记录技术（55）和荧光离子敏感染料的视频成像（53,131）的出现，使人们对免疫系统中单个细胞的反应有了新的关注。在这篇综述中，我们介绍了在单细胞水平上探索T和B淋巴细胞离子通道功能的最新进展，特别强调了三种淋巴细胞行为：细胞活化和有丝分裂，细胞毒性和体积调节。
T and B lymphocytes play fundamental and diverse roles in the immune response, which include recognition of antigens, secretion of lymphokines and antibodies, and killing of foreign or virus-infected cells. Ionic fluxes associated with lymphocyte activation, mitogenesis, and volume regulation have been studied extensively in cell suspensions (for reviews, see 67, 103, 124, Grinstein & Foskett, this volume). More recently, the advent of patchclamp recording techniques (55) and video imaging of fluorescent ionsensitive dyes (53, 131) has placed a new emphasis on the responses individual cells in the immune system. In this review we address recent advances in the exploration of ion-channel functions in T and B lymphocytes at the single-cell level, with particular emphasis on three lymphocyte behaviors: cell activation and mitogenesis, cytotoxicity, and volume regulation.