Cerebrospinal fluid interleukin-6 in progressive neuro-Behcet's syndrome
Cerebrospinal fluid interleukin-6 in progressive neuro-Behcet's syndrome
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DOI：
10.1006/clin.1996.4268
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发表时间：
1997-01-01
期刊：
影响因子：
--
通讯作者：
Hashimoto, T
中科院分区：
文献类型：
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作者：
Hirohata, S;Isshi, K;Hashimoto, T
中枢神经系统（CNS）受累于白塞氏病，通常称为神经-白塞氏综合征（NB），是该病最严重的并发症之一。本研究检测了NE患者脑脊液（CSF）白介素-6 （IL-6）活性，以探讨其与进行性中枢神经系统疾病的相关性。通过仔细的临床观察，从11例被诊断为进展性NE的患者和11例活动性Behcet病但没有进展性中枢神经系统疾病的患者中获得配对的CSF和血清标本。采用IL-6依赖性小鼠杂交瘤MH60检测脑脊液和血清中IL-6水平。BSF2细胞。11例进展性NE患者脑脊液IL-6活性均明显升高[0.18-3.90 U/ml, 1.19 +/- 1.18（平均+/- SD）正常范围]；
Central nervous system (CNS) involvement in Behcet's disease, usually called neuro-Behcet's syndrome (NB), is one of the most serious complications of the disease. The present study examined cerebrospinal fluid (CSF) interleukin-6 (IL-6) activity in patients with NE to explore its relevance to the progressive CNS disease. Paired CSF and serum specimens were obtained from 11 patients who were diagnosed as having progressive NE based on careful clinical observation and from 11 patients with active Behcet's disease but lacking progressive CNS disease. IL-6 levels in the CSF and sera were determined using IL-6-dependent murine hybridoma MH60.BSF2 cells. All 11 patients with progressive NE showed marked elevation of CSF IL-6 activity [0.18-3.90 U/ml, 1.19 +/- 1.18 (mean +/- SD) normal range,