On the elevated plus maze the anxiolytic like effects of the 5-HT1A agonist, 8-OH-DPAT, but not the anxiogenic-like effects of the 5-HT1A partial agonist, buspirone, are blocked by the 5-HT1A antagonist, WAY 100635
On the elevated plus maze the anxiolytic like effects of the 5-HT1A agonist, 8-OH-DPAT, but not the anxiogenic-like effects of the 5-HT1A partial agonist, buspirone, are blocked by the 5-HT1A antagonist, WAY 100635
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DOI：
10.1007/s002130050317
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发表时间：
1997-07-01
影响因子：
3.4
通讯作者：
Dawson, GR
中科院分区：
文献类型：
--
作者：
Collinson, N;Dawson, GR
在本研究中，我们评价了5-HT 1A受体部分激动剂盐酸丁螺环酮和5-HT 1A受体激动剂8-羟基-2-（二正丙基氨基）四氢萘（8-OH-DPAT）对高架十字迷宫的影响。此外，测定了5-HT 1A受体拮抗剂WAY 100635逆转两种化合物作用的能力。8-OH-DPAT（0.01-0.3 mg/kg，SC）剂量依赖性地增加了迷宫开放臂的时间百分比和进入次数。在第二项实验中，WAY 100635（0.003-0.3 mg/kg，SC）剂量依赖性逆转8-OH-DPAT（0.3 mg/kg，SC）的抗焦虑样作用。在第三个实验中，丁螺环酮（0.3-4.0 mg/kg，SC）剂量依赖性地减少了在迷宫开放臂上花费的时间，表明其具有焦虑样作用。丁螺环酮还显著降低了自发活动，这在张开的手臂上行进的距离减少中是明显的。闭合臂和迷宫作为一个整体，臂进入的总数和动物的平均速度。与其在迷宫中对8-OH-DPAT诱导行为的作用相反，WAY 100635（0.003-1.0 mg/kg SC）未能逆转丁螺环酮诱导的任何作用。高剂量WAY 100635（0.3-1.0 mg/kg SC）单独给药的动物与溶媒给药动物在高架十字迷宫试验期间记录的任何测量值均无显著差异。这些数据表明，8-OH-DPAT对高架十字迷宫的抗焦虑样作用，而不是丁螺环酮的致焦虑样作用，是通过CNS中的S-HT 1A受体介导的。
In the present study we evaluated the effects of the 5-HT1A receptor partial agonist, buspirone hydrochloride and the 5-HT1A receptor agonist, 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) on the elevated plus-maze. In addition, the ability of the 5-HT1A receptor antagonist, WAY 100635, to reverse the effects of both compounds was determined. 8-OH-DPAT (0.01-0.3 mg/kg, SC) dose-dependently increased the percent time on, and the number of entries to, the open arms of the maze. In a second experiment, WAY 100635 (0.003-0.3 mg/kg, SC) dose-dependently reversed the anxiolytic-like effects of 8-OH-DPAT (0.3 mg/kg, SC). In a third experiment, buspirone (0.3-4.0 mg/kg, SC) dose-dependently decreased the time spent on the open arms of the maze, indicating that it had anxiogenic-like effects. Buspirone also significantly decreased locomotor activity, which was evident in the decreases in the distance travelled on the open arms. closed arms and on the maze as a whole, the total number of arm entries and the mean speed of the animals. In contrast to its effects on 8-OH-DPAT-induced behaviours in the maze, WAY 100635 (0.003-1.0 mg/kg SC) failed to reverse any of the effects induced by buspirone. Animals treated with high doses of WAY 100635 (0.3-1.0 mg/kg SC) alone did not significantly differ from vehicle-treated animals on any of the measures recorded during elevated plus-maze trials. These data suggest that the anxiolytic-like effects of 8-OH-DPAT, but not the anxiogenic-like effects of buspirone, on the elevated plus-maze are mediated via S-HT1A receptors in the CNS.