Chemical Constituents and Biological Activities of Plants from the Genus Physalis
Chemical Constituents and Biological Activities of Plants from the Genus Physalis
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DOI：
10.1002/cbdv.201400435
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发表时间：
2016-01
影响因子：
2.9
通讯作者：
Wenna Zhang;W. Tong
中科院分区：
文献类型：
--
作者：
Wenna Zhang;W. Tong
1. Introduction.–Physalis is a genus of herbaceous plants in the Solanaceae family. The genus comprises approximately 120 species, mainly distributed in America tropical and temperate regions [1]. Most species of the genus Physalis have been used for a long time in the ethnomedical folk traditions of Asian and American populations to treat different illnesses, such as malaria, asthma, hepatitis, dermatitis, liver disorders, and as an antimycobacterial, anticancer, antileukemic, antipyretic, and immuno-modulatory agent [2][3]. Moreover, some species are cultivated or gathered from wild populations for their edible fruits. Recently, increasing attention has been paid to the Physalis genus on the phytochemistry and pharmacology [4–7]. In this article, due to the wide variety of chemical constituents, we aim at providing an overview of the phytochemical progress and listing the compounds isolated from Physalis over the period from 1995 to 2014. The biological activities of the crude extracts and isolated compounds of this genus are also included. This review is intended to compile the constituents, verify their bioactivities, indicate potential leads for future drug design, and thus, provide a reference for further research and the application of Physalis.2. Chemical Constituents.–A total of 216 chemical constituents have been obtained from the genus Physalis over the past two decades, including withanolides (1–169), labdane diterpenes (170–174), sucrose esters (175–189), flavonoids (190–203), ceramides (204–206), and others (207–216). Their structures are shown below, and their names and the corresponding plant sources are compiled in the Table.
