Wireless magnetothermal deep brain stimulation
Wireless magnetothermal deep brain stimulation
复制标题
DOI：
10.1126/science.1261821
复制
发表时间：
2015-03-27
期刊：
影响因子：
56.9
通讯作者：
Anikeeva, Polina
中科院分区：
文献类型：
--
作者：
Chen, Ritchie;Romero, Gabriela;Anikeeva, Polina
对定义明确的神经元群进行无线脑深部刺激可以促进完整脑回路的研究和神经系统疾病的治疗。在这里，我们展示了通过磁性纳米颗粒激活热敏辣椒素受体TRPV1的微创和远程神经兴奋。当暴露在交变磁场中时，纳米颗粒会散发由迟滞产生的热量，触发TRPV1（+）神经元广泛且可逆的放电。无线磁热刺激小鼠腹侧被盖区可引起目标脑区和接受兴奋性投射结构的神经元亚群的兴奋。纳米颗粒在大脑中持续存在一个多月，无需植入物和连接器即可实现慢性刺激。
Wireless deep brain stimulation of well-defined neuronal populations could facilitate the study of intact brain circuits and the treatment of neurological disorders. Here, we demonstrate minimally invasive and remote neural excitation through the activation of the heat-sensitive capsaicin receptor TRPV1 by magnetic nanoparticles. When exposed to alternating magnetic fields, the nanoparticles dissipate heat generated by hysteresis, triggering widespread and reversible firing of TRPV1(+) neurons. Wireless magnetothermal stimulation in the ventral tegmental area of mice evoked excitation in subpopulations of neurons in the targeted brain region and in structures receiving excitatory projections. The nanoparticles persisted in the brain for over a month, allowing for chronic stimulation without the need for implants and connectors.